ArticleJournal of bacteriology2005
Regulation of finP transcription by DNA adenine methylation in the virulence plasmid of Salmonella enterica.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- ThemBio · 2025Article
- Genetic and phenotypic analysis of the virulence plasmid of a non-Shigatoxigenic enteroaggregativeMicrobiology (Reading, England) · 2025Article
- Article
- In Situ Monitoring and Quantitative Determination of R27 Plasmid Conjugation.Life (Basel, Switzerland) · 2022Article
- Novel Identification of Bacterial Epigenetic Regulations Would Benefit From a Better Exploitation of Methylomic Data.Frontiers in microbiology · 2021Review
- Plasmid Transfer by Conjugation in Gram-Negative Bacteria: From the Cellular to the Community Level.Genes · 2020Review
- Methyltransferase DnmA is responsible for genome-wide N6-methyladenosine modifications at non-palindromic recognition sites in Bacillus subtilis.Nucleic acids research · 2020Article
- Fur-Dam Regulatory Interplay at an Internal Promoter of the Enteroaggregative Escherichia coli Type VI SecretionJournal of bacteriology · 2020Article
- Copy Number Heterogeneity in the Virulence Plasmid ofFrontiers in microbiology · 2020Article
- The bacterial epigenome.Nature reviews. Microbiology · 2020Review
- Divergent methylation of CRISPR repeats and cas genes in a subtype I-D CRISPR-Cas-system.BMC microbiology · 2019Article
- N4-cytosine DNA methylation regulates transcription and pathogenesis in Helicobacter pylori.Nucleic acids research · 2018Article
- A role for the bacterial GATC methylome in antibiotic stress survival.Nature genetics · 2016Article
- DNA Methylation.EcoSal Plus · 2014Article
- Computational discovery and RT-PCR validation of novel Burkholderia conserved and Burkholderia pseudomallei unique sRNAs.BMC genomics · 2012Article
- Phase variation controls expression of Salmonella lipopolysaccharide modification genes by a DNA methylation-dependent mechanism.Molecular microbiology · 2010Article
- Regulation of bacterial conjugation in microaerobiosis by host-encoded functions ArcAB and sdhABCD.Genetics · 2010Article
- Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more.FEMS microbiology reviews · 2009Review
- Regulation of the Salmonella enterica std fimbrial operon by DNA adenine methylation, SeqA, and HdfR.Journal of bacteriology · 2008Article
- Conjugal transfer of the Salmonella enterica virulence plasmid in the mouse intestine.Journal of bacteriology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA adenine methylase (Dam(-)) mutants of Salmonella enterica serovar Typhimurium contain reduced levels of FinP RNA encoded on the virulence plasmid. Dam methylation appears to regulate finP transcription, rather than FinP RNA stability or turnover. The finP promoter includes canonical -10 and -35 modules and depends on the sigma(70) factor. Regulation of finP transcription by Dam methylation does not require DNA sequences upstream from the -35 module, indicating that Dam acts at the promoter itself or downstream. Unexpectedly, a GATC site overlapping with the -10 module is likewise dispensable for Dam-mediated regulation. These observations indicate that Dam methylation regulates finP transcription indirectly and suggest the involvement of a host factor(s) responsive to the Dam methylation state of the cell. We provide evidence that one such factor is the nucleoid protein H-NS, which acts as a repressor of finP transcription in a Dam(-) background. H-NS also restrains transcription of the overlapping traJ gene, albeit in a Dam-independent fashion. Hence, the decreased FinP RNA content found in Dam(-) hosts of S. enterica appears to result from H-NS-mediated repression of finP transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.