ArticleJournal of bacteriology2005
FpvIR control of fpvA ferric pyoverdine receptor gene expression in Pseudomonas aeruginosa: demonstration of an interaction between FpvI and FpvR and identification of mutations in each compromising this interaction.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Phage-Mediated Iron Acquisition bybioRxiv : the preprint server for biology · 2026Article
- Molecular mechanism of siderophore regulation by the Pseudomonas aeruginosa BfmRS two-component system in response to osmotic stress.Communications biology · 2024Article
- Stringent Starvation Protein SspA and Iron Starvation Sigma Factor PvdS Coordinately Regulate Iron Uptake and Prodiginine Biosynthesis inApplied and environmental microbiology · 2022Article
- Plant growth-promoting effect and genomic analysis of the P. putida LWPZF isolated from C. japonicum rhizosphere.AMB Express · 2022Article
- Transcription regulation of iron carrier transport genes by ECF sigma factors through signaling from the cell surface into the cytoplasm.FEMS microbiology reviews · 2022Article
- Machine learning from Pseudomonas aeruginosa transcriptomes identifies independently modulated sets of genes associated with known transcriptional regulators.Nucleic acids research · 2022Article
- Axial Heme Coordination by the Tyr-His Motif in the Extracellular Hemophore HasAp Is Critical for the Release of Heme to the HasR Receptor ofBiochemistry · 2021Article
- Post-transcriptional regulation of theThe Journal of biological chemistry · 2019Article
- The biosynthesis of pyoverdines.Microbial cell (Graz, Austria) · 2018Review
- Chalkophores.Annual review of biochemistry · 2018Review
- Integration of Transcriptomic and Proteomic Approaches Reveals the Temperature-Dependent Virulence ofFrontiers in cellular and infection microbiology · 2018Article
- Dual-seq transcriptomics reveals the battle for iron during Pseudomonas aeruginosa acute murine pneumonia.Scientific reports · 2016Article
- Long-term social dynamics drive loss of function in pathogenic bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Interactions between an anti-sigma protein and two sigma factors that regulate the pyoverdine signaling pathway in Pseudomonas aeruginosa.BMC microbiology · 2014Article
- Deciphering protein dynamics of the siderophore pyoverdine pathway in Pseudomonas aeruginosa.PloS one · 2013Article
- A novel role for an ECF sigma factor in fatty acid biosynthesis and membrane fluidity in Pseudomonas aeruginosa.PloS one · 2013Article
- Pseudomonas aeruginosa adapts its iron uptake strategies in function of the type of infections.Frontiers in cellular and infection microbiology · 2013Review
- Mini-review: Lactoferrin: a bioinspired, anti-biofilm therapeutic.Biofouling · 2013Review
- The soluble pyocins S2 and S4 from Pseudomonas aeruginosa bind to the same FpvAI receptor.MicrobiologyOpen · 2012Article
- A Novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa.PLoS pathogens · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FpvR is a presumed cytoplasmic membrane-associated anti-sigma factor that controls the activities of extracytoplasmic function sigma factors PvdS and FpvI responsible for transcription of pyoverdine biosynthetic genes and the ferric pyoverdine receptor gene, fpvA, respectively. Using deletion analysis and an in vivo bacterial two-hybrid system, FpvR interaction with these sigma factors was confirmed and shown to involve the cytoplasmic N-terminal 67 amino acid resides of FpvR. FpvR bound specifically to a C-terminal region of FpvI corresponding to region 4 of the sigma(70) family of sigma factors. FpvR and FpvI mutant proteins compromised for this interaction were generated by random and site-directed PCR mutagenesis and invariably contained secondary structure-altering proline substitution in predicted alpha-helices within the FpvR N terminus or FpvI region 4. PvdS was shown to bind to the same N-terminal region of FpvR, and FpvR mutations compromising FpvI binding also compromised PvdS binding, although some mutations had a markedly greater impact on PvdS binding. Apparently, these two sigma factors bind to FpvR in a substantially similar but not identical fashion. Intriguingly, defects in FpvR binding correlated with a substantial drop in yields of the FpvI and to a lesser extent PvdS sigma factors, suggesting that FpvR-bound FpvI and PvdS are stable while free and active sigma factor is prone to turnover.
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