ArticleJournal of bacteriology2005
The agr radiation: an early event in the evolution of staphylococci.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 117 citations in OpenAlex.
- Characterization of infecting strains and superantigen-neutralizing antibodies in Staphylococcus aureus bacteremia.Clinical and vaccine immunology : CVI · 2011Trial
- Single-cell approach dissecting agr quorum sensing dynamics in Staphylococcus aureus.Nature communications · 2026Article
- Molecular Mechanisms of Virulence Regulation inAccounts of chemical research · 2025Article
- Mucin-induced surface dispersal ofmBio · 2024Article
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Chemical and biomolecular insights into theIsrael journal of chemistry · 2023Article
- Analysis of the Presence of the Virulence and Regulation Genes fromInternational journal of environmental research and public health · 2023Article
- Characterization of MroQ-Dependent Maturation and Export of the Staphylococcus aureus Accessory Gene Regulatory System Autoinducing Peptide.Infection and immunity · 2022Article
- Reconstitution of theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Direct Quantitative Immunochemical Analysis of Autoinducer Peptide IV for Diagnosing and StratifyingACS infectious diseases · 2022Article
- Species-Wide Phylogenomics of the Staphylococcus aureusMicrobiology spectrum · 2022Article
- Nonconformity of biofilm formation in vivo and in vitro based on Staphylococcus aureus accessory gene regulator status.Scientific reports · 2022Article
- Engineering a "detect and destroy" skin probiotic to combat methicillin-resistant Staphylococcus aureus.PloS one · 2022Article
- Accessory Gene Regulator (Frontiers in microbiology · 2022Article
- Clinical and molecular characteristics of Staphylococcus aureus isolated from Chinese children: association among the agr groups and genotypes, virulence genes and disease types.World journal of pediatrics : WJP · 2021Article
- Antibiotic resistance and typing ofIranian journal of basic medical sciences · 2020Article
- Article
- Observational
- The gelatinase biosynthesis-activating pheromone binds and stabilises the FsrB membrane protein in Enterococcus faecalis quorum sensing.FEBS letters · 2020Article
- Characterization ofmSphere · 2019Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Agr is a global regulatory system in the staphylococci, operating by a classical two-component signaling module and controlling the expression of most of the genes encoding extracellular virulence factors. As it is autoinduced by a peptide, encoded within the locus, that is the ligand for the signal receptor, it is a sensor of population density or a quorum sensor and is the only known quorum-sensing system in the genus. agr is conserved throughout the staphylococci but has diverged along lines that appear to parallel speciation and subspeciation within the genus. This divergence has given rise to a novel type of interstrain and interspecies cross-inhibition that represents a fundamental aspect of the organism's biology and may be a predominant feature of the evolutionary forces that have driven it. We present evidence, using a newly developed, luciferase-based agr typing scheme, that the evolutionary divergence of the agr system was an early event in the evolution of the staphylococci and long preceded the development of the nucleotide polymorphisms presently used for genotyping. These polymorphisms developed, for the most part, within different agr groups; mobile genetic elements appear also to have diffused recently and, with a few notable exceptions, have come to reside largely indiscriminately within the several agr groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.