ArticleGenome research2005
An extraordinary retrotransposon family encoding dual endonucleases.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- High Throughput Characterization of Eukaryotic 2A-Like Peptides Identifies Novel Leucine-Associated Reduction in Protein Abundance.bioRxiv : the preprint server for biology · 2026Article
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- Rates and spectra of de novo structural mutations inGenome research · 2023Article
- An Ancient Clade of Penelope-Like Retroelements with Permuted Domains Is Present in the Green Lineage and Protists, and Dominates Many Invertebrate Genomes.Molecular biology and evolution · 2021Article
- Comparative genomics of Chlamydomonas.The Plant cell · 2021Article
- Involvement of Conserved Amino Acids in the C-Terminal Region of LINE-1 ORF2p in Retrotransposition.Genetics · 2017Article
- Convergence of retrotransposons in oomycetes and plants.Mobile DNA · 2017Article
- Reverse transcriptase genes are highly abundant and transcriptionally active in marine plankton assemblages.The ISME journal · 2016Article
- Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution.Microbiology spectrum · 2015Review
- Ancient Origin of the U2 Small Nuclear RNA Gene-Targeting Non-LTR Retrotransposons Utopia.PloS one · 2015Article
- Acquisition of Full-Length Viral Helicase Domains by Insect Retrotransposon-Encoded Polypeptides.Frontiers in microbiology · 2015Article
- Preferential occupancy of R2 retroelements on the B chromosomes of the grasshopper Eyprepocnemis plorans.PloS one · 2014Article
- Acquisition of an Archaea-like ribonuclease H domain by plant L1 retrotransposons supports modular evolution.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Endonuclease domain of the Drosophila melanogaster R2 non-LTR retrotransposon and related retroelements: a new model for transposition.Frontiers in genetics · 2013Article
- RNA-Mediated Gene Duplication and Retroposons: Retrogenes, LINEs, SINEs, and Sequence Specificity.International journal of evolutionary biology · 2013Article
- Crypton transposons: identification of new diverse families and ancient domestication events.Mobile DNA · 2011Article
- Article
- Non-LTR retrotransposons in fungi.Functional & integrative genomics · 2009Article
- CR1 clade of non-LTR retrotransposons from Maculinea butterflies (Lepidoptera: Lycaenidae): evidence for recent horizontal transmission.BMC evolutionary biology · 2007Article
- Characterization of the sequence specificity of the R1Bm endonuclease domain by structural and biochemical studies.Nucleic acids research · 2007Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retrotransposons commonly encode a reverse transcriptase (RT), but other functional domains are variable. The acquisition of new domains is the dominant evolutionary force that brings structural variety to retrotransposons. Non-long-terminal-repeat (non-LTR) retrotransposons are classified into two groups by their structure. Early branched non-LTR retrotransposons encode a restriction-like endonuclease (RLE), and recently branched non-LTR retrotransposons encode an apurinic/apyrimidinic endonuclease-like endonuclease (APE). In this study, we report a novel non-LTR retrotransposon family Dualen, identified from the Chlamydomonas reinhardtii genome. Dualen encodes two endonucleases, RLE and APE, with RT, ribonuclease H, and cysteine protease. Phylogenetic analyses of the RT domains revealed that Dualen is positioned at the midpoint between the early-branched and the recently branched groups. In the APE tree, Dualen was branched earlier than the I group and the Jockey group. The ribonuclease H domains among the Dualen family and other non-LTR retrotransposons are monophyletic. Phylogenies of three domains revealed the monophyly of the Dualen family members. The domain structure and the phylogeny of each domain imply that Dualen is a retrotransposon conserving the domain structure just after the acquisition of APE. From these observations, we discuss the evolution of domain structure of non-LTR retrotransposons.
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