ArticleProceedings of the National Academy of Sciences of the United States of America2005
Parallel evolution of chimeric fusion genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 69 citations in OpenAlex.
- Evolutionary innovation through fusion of sequences from across the tree of life.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Maize β-amylase7 encodes 2 proteins using alternative transcriptional start sites: Nuclear BAM7 and plastidic BAM2.Plant physiology · 2023Article
- Strong, Recent Selective Sweeps Reshape Genetic Diversity in Freshwater Bivalve Megalonaias nervosa.Molecular biology and evolution · 2023Article
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- Evolutionary patterns of chimeric retrogenes in Oryza species.Scientific reports · 2019Article
- De novo gene birth.PLoS genetics · 2019Article
- The Genomic Impact of Gene Retrocopies: What Have We Learned from Comparative Genomics, Population Genomics, and Transcriptomic Analyses?Genome biology and evolution · 2017Article
- Tandem duplications lead to novel expression patterns through exon shuffling in Drosophila yakuba.PLoS genetics · 2017Article
- Altered Transcription and Neofunctionalization of Duplicated Genes Rescue the Harmful Effects of a Chimeric Gene inThe Plant cell · 2016Article
- Tandem Duplications and the Limits of Natural Selection in Drosophila yakuba and Drosophila simulans.PloS one · 2015Article
- Landscape of standing variation for tandem duplications in Drosophila yakuba and Drosophila simulans.Molecular biology and evolution · 2014Article
- Diverse alkane hydroxylase genes in microorganisms and environments.Scientific reports · 2014Article
- Repeated evolution of chimeric fusion genes in the β-globin gene family of laurasiatherian mammals.Genome biology and evolution · 2014Article
- The lineage-specific evolution of aquaporin gene clusters facilitated tetrapod terrestrial adaptation.PloS one · 2014Article
- Genome-wide analysis of the NADK gene family in plants.PloS one · 2014Article
- 3-to-1: unraveling structural transitions in ureases.Die Naturwissenschaften · 2013Article
- Gene copy-number polymorphism caused by retrotransposition in humans.PLoS genetics · 2013Article
- New gene evolution: little did we know.Annual review of genetics · 2013Review
- High occurrence of functional new chimeric genes in survey of rice chromosome 3 short arm genome sequences.Genome biology and evolution · 2013Article
- Chimeric genes as a source of rapid evolution in Drosophila melanogaster.Molecular biology and evolution · 2012Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand how novel functions arise, we must identify common patterns and mechanisms shaping the evolution of new genes. Here, we take advantage of data from three Drosophila genes, jingwei, Adh-Finnegan, and Adh-Twain, to find evolutionary patterns and mechanisms governing the evolution of new genes. All three of these genes are independently derived from Adh, which enabled us to use the extensive literature on Adh in Drosophila to guide our analyses. We discovered a fundamental similarity in the temporal, spatial, and types of amino acid changes that occurred. All three genes underwent rapid adaptive amino acid evolution shortly after they were formed, followed by later quiescence and functional constraint. These genes also show striking parallels in which amino acids change in the Adh region. We showed that these early changes tend to occur at amino acid residues that seldom, if ever, evolve in Drosophila Adh. Changes at these slowly evolving sites are usually associated with loss of function or hypomorphic mutations in Drosophila melanogaster. Our data indicate that shifting away from ancestral functions may be a critical step early in the evolution of chimeric fusion genes. We suggest that the patterns we observed are both general and predictive.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.