ArticleJournal of neural transmission (Vienna, Austria : 1996)2006
Linkage analyses of chromosomal region 18p11-q12 in dyslexia.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- The genetics of reading disabilities: from phenotypes to candidate genes.Frontiers in psychology · 2012Article
- In search of the perfect phenotype: an analysis of linkage and association studies of reading and reading-related processes.Behavior genetics · 2011Review
- Genome scan for spelling deficits: effects of verbal IQ on models of transmission and trait gene localization.Behavior genetics · 2011Article
- Article
- Genetics of developmental dyslexia.European child & adolescent psychiatry · 2010Review
- Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.BMC medical genetics · 2007Article
- Developmental dyslexia: an update.Journal of human genetics · 2007Review
- Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia.American journal of human genetics · 2006Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dyslexia is characterized as a significant impairment in reading and spelling ability that cannot be explained by low intelligence, low school attendance or deficits in sensory acuity. It is known to be a hereditary disorder that affects about 5% of school aged children, making it the most common of childhood learning disorders. Several susceptibility loci have been reported on chromosomes 1, 2, 3, 6, 15, and 18. The locus on chromosome 18 has been described as having the strongest influence on single word reading, phoneme awareness, and orthographic coding in the largest genome wide linkage study published to date (Fisher et al., 2002). Here we present data from 82 German families in order to investigate linkage of various dyslexia-related traits to the previously described region on chromosome 18p11-q12. Using two- and multipoint analyses, we did not find support for linkage of spelling, single word reading, phoneme awareness, orthographic coding and rapid naming to any of the 14 genotyped STR markers. Possible explanations for our non-replication include differences in study design, limited power of our study and overestimation of the effect of the chromosome 18 locus in the original study.
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Registered trials
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