ArticleThe Journal of clinical investigation2005
Insulin infusion in acute illness.
Article in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02574156 (Control of Hyperglycemia After Cardiac Surgery), which is not on this map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Control of Hyperglycemia After Cardiac Surgery: CHyCS Trial
Who cites it
40 citing papers in PubMed, 148 citations in OpenAlex.
- Insulin suppresses endotoxin-induced oxidative, nitrosative, and inflammatory stress in humans.Diabetes care · 2010Trial
- Systemic inflammation response index (SIRI)-based risk of pneumonia following successful PCI in STEMI patients.Annals of medicine · 2025Article
- Elevated stress hyperglycemia ratio associated with higher hospital mortality in patients with respiratory failure.Scientific reports · 2025Article
- Respiratory Outcomes of Insulin Use in Patients with COPD: A Nationwide Population-Based Cohort Study.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Positive association between stress hyperglycemia ratio and pulmonary infection in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention.Cardiovascular diabetology · 2023Article
- Impact of exercise on renal function, oxidative stress, and systemic inflammation among patients with type 2 diabetic nephropathy.African health sciences · 2022Article
- Mechanisms Linking COPD to Type 1 and 2 Diabetes Mellitus: Is There a Relationship between Diabetes and COPD?Medicina (Kaunas, Lithuania) · 2022Review
- The effect of short-term intensive insulin therapy on inflammatory cytokines in patients with newly diagnosed type 2 diabetes.Journal of diabetes · 2022Article
- Higher Stress Hyperglycemia Ratio Is Associated With a Higher Risk of Stroke-Associated Pneumonia.Frontiers in nutrition · 2022Article
- Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD.Journal of translational medicine · 2021Article
- The Cytokine Profiles and Immune Response Are Increased in COVID-19 Patients with Type 2 Diabetes Mellitus.Journal of diabetes research · 2021Article
- 3D kernel-density stochastic model for more personalized glycaemic control: development and in-silico validation.Biomedical engineering online · 2019Article
- Perioperative Management of Hyperglycemia and Diabetes in Cardiac Surgery Patients.Endocrinology and metabolism clinics of North America · 2018Review
- Convenient food made of extruded adzuki bean attenuates inflammation and improves glycemic control in patients with type 2 diabetes: a randomized controlled trial.Therapeutics and clinical risk management · 2018Article
- Untangling glycaemia and mortality in critical care.Critical care (London, England) · 2017Article
- Phenotypic Characterization of Human Monocytes following Macronutrient Intake in Healthy Humans.Frontiers in immunology · 2017Article
- Effect of local insulin injection on wound vascularization in patients with diabetic foot ulcer.Experimental and therapeutic medicine · 2016Article
- Non-ICU hospital care of diabetes mellitus in the elderly population.Current diabetes reports · 2015Review
- Diet is critical for prolonged glycemic control after short-term insulin treatment in high-fat diet-induced type 2 diabetic male mice.PloS one · 2015Article
- Pharmacotherapy for Hyperglycemia in Noncritically Ill Hospitalized Patients.Diabetes spectrum : a publication of the American Diabetes Association · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discovery of the antiinflammatory effect of insulin and the proinflammatory effect of glucose has not only provided novel insight into the mechanisms underlying several disease states but has also provided a rationale for the treatment of hyperglycemia in several acute clinical conditions. Van den Berghe et al. previously showed the benefits of intensive glycemic control with insulin in patients admitted to intensive care units. In this issue of the JCI, the same group of investigators now demonstrates that infusion of insulin to restore euglycemia in these patients results in a marked reduction in inflammatory indices such as adhesion molecules, hepatic iNOS, and plasma NO metabolites. The reduction in the mediators of inflammation may thus be responsible for the impressive improvement in clinical outcomes following insulin therapy, and the results suggest a new paradigm in which glucose and insulin are related not only through their metabolic actions but also through their opposite effects on inflammatory mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.