ArticleThe Journal of cell biology1992
Gas2, a growth arrest-specific protein, is a component of the microfilament network system.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 124 citations in OpenAlex.
- Insights into Structure and Function of Growth Arrest Specific 2 (GAS2).Journal of Cancer · 2025Review
- Growth arrest-specific protein 2 (GAS2) interacts with CXCR4 to promote T-cell leukemogenesis partially via c-MYC.Molecular oncology · 2022Article
- Genome-wide DNA methylation and gene expression patterns of androgenetic haploid tiger pufferfish (Takifugu rubripes) provide insights into haploid syndrome.Scientific reports · 2022Article
- Comparative iTRAQ proteomics identified proteins associated with sperm maturation between yak and cattleyak epididymis.BMC veterinary research · 2021Article
- Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.Developmental cell · 2021Article
- Integrative analysis regarding the correlation between GAS2 family genes and human glioma prognosis.Cancer medicine · 2021Article
- Growth arrest-specific 2 protein family: Structure and function.Cell proliferation · 2021Review
- The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma.International journal of molecular sciences · 2020Review
- GAS2 Promotes Cell Proliferation and Invasion and Suppresses Apoptosis in Pediatric T-Cell Acute Lymphoblastic Leukemia and Activates Wnt/β-Catenin Pathway.OncoTargets and therapy · 2020Article
- Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis.World journal of gastroenterology · 2019Article
- The binding landscape of a partially-selective isopeptidase inhibitor with potent pro-death activity, based on the bis(arylidene)cyclohexanone scaffold.Cell death & disease · 2018Article
- Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Growth arrest specific gene 2 in tilapia (Oreochromis niloticus): molecular characterization and functional analysis under low-temperature stress.BMC molecular biology · 2017Article
- Growth Arrest Specific 2 (GAS2) is a Critical Mediator of Germ Cell Cyst Breakdown and Folliculogenesis in Mice.Scientific reports · 2016Article
- The Gas2 family protein Pigs is a microtubule +TIP that affects cytoskeleton organisation.Journal of cell science · 2016Article
- Alternative RNA structure-coupled gene regulations in tumorigenesis.International journal of molecular sciences · 2014Review
- Article
- GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins.Journal of cell science · 2014Article
- Growth arrest specific 2 is up-regulated in chronic myeloid leukemia cells and required for their growth.PloS one · 2014Article
- Gas2l3, a novel constriction site-associated protein whose regulation is mediated by the APC/C Cdh1 complex.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this report we analyze the protein product of a growth arrest-specific gene, gas2, by means of an affinity-purified antibody raised against the protein produced in bacteria. The regulation of Gas2 biosynthesis reflects the pattern of mRNA expression (Schneider, C., R. King, and L. Philipson. 1988. Cell. 54:787-793): its relative level is tightly associated with growth arrest. Gas2 seems to be regulated also at the posttranslational level via a phosphorylation mechanism. Gas2 is well conserved during the evolution with the same apparent molecular mass (36 kD) between mouse and human. We also demonstrate that Gas2 is a component of the microfilament system. It colocalizes with actin fiber, at the cell border and also along the stress fiber, in growth-arrested NIH 3T3 cells. The pattern of distribution, detected in arrested cells, can also be observed in growing cells when they are microinjected with the purified GST-Gas2 protein. In none of the analyzed oncogene-transformed NIH 3T3 cell lines was Gas2 expression induced under serum starvation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.