ArticleNucleic acids research2005
An Oct-1 binding site mediates activation of the gata2 promoter by BMP signaling.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Machine learning predicts nucleosome binding modes of transcription factors.BMC bioinformatics · 2021Article
- GATA2 is required for lymphatic vessel valve development and maintenance.The Journal of clinical investigation · 2015Article
- SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster.The Journal of biological chemistry · 2013Article
- Article
- Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate.PLoS computational biology · 2010Article
- A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes.Oncogene · 2009Article
- An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules.BMC systems biology · 2009Article
- Combinatorial regulation of novel erythroid gene expression in zebrafish.Experimental hematology · 2008Article
- Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish.BMC developmental biology · 2007Article
- Tid1 is a Smad-binding protein that can modulate Smad7 activity in developing embryos.The Biochemical journal · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The gata2 gene encodes a transcription factor implicated in regulating early patterning of ectoderm and mesoderm, and later in numerous cell-specific gene expression programs. Activation of the gata2 gene during embryogenesis is dependent on the bone morphogenetic protein (BMP) signaling pathway, but the mechanism for how signaling controls gene activity has not been defined. We developed an assay in Xenopus embryos to analyze regulatory sequences of the zebrafish gata2 promoter that are necessary to mediate the response to BMP signaling during embryogenesis. We show that activation is Smad dependent, since it is blocked by expression of the inhibitory Smad6. Deletion analysis identified an octamer binding site that is necessary for BMP-mediated induction, and that interacts with the POU homeodomain protein Oct-1. However, this element is not sufficient to transfer a BMP response to a heterologous promoter, requiring an additional more proximal cooperating element. Based on recent studies with other BMP-dependent promoters (Drosophila vestigial and Xenopus Xvent-2), our studies of the gata2 gene suggest that POU-domain proteins comprise a common component of the BMP signaling pathway, cooperating with Smad proteins and other transcriptional activators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.