ReviewThe Journal of experimental medicine2005
Balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus.
Review in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Restoring B cell intrinsic tolerance to lupus autoimmunity: a rational strategy for lupus treatment.Frontiers in immunology · 2026Review
- Siglec-H-Deficient Mice Show Enhanced Type I IFN Responses, but Do Not Develop Autoimmunity After Influenza or LCMV Infections.Frontiers in immunology · 2021Article
- Immune cell subset differentiation and tissue inflammation.Journal of hematology & oncology · 2018Review
- The composition and variation of the BCR CDR3s in gastric cancer.Oncology letters · 2018Article
- Phenotyping of autoreactive B cells with labeled nucleosomes in 56R transgenic mice.Scientific reports · 2017Article
- Identification of autoreactive B cells with labeled nucleosomes.Scientific reports · 2017Article
- Immunosuppressive Effect of B7-H4 Pathway in a Murine Systemic Lupus Erythematosus Model.Frontiers in immunology · 2017Article
- Direct measurement of B-cell receptor repertoire's composition and variation in systemic lupus erythematosus.Genes and immunity · 2017Article
- Siglec-H protects from virus-triggered severe systemic autoimmunity.The Journal of experimental medicine · 2016Article
- Broadened T-cell repertoire diversity in ivIg-treated SLE patients is also related to the individual status of regulatory T-cells.Journal of clinical immunology · 2013Article
- IgM Repertoire Biodiversity is Reduced in HIV-1 Infection and Systemic Lupus Erythematosus.Frontiers in immunology · 2013Article
- B-cell targeted therapy in systemic lupus erythematosus: potential of rituximab.Biologics : targets & therapy · 2012Article
- Lupus nephritis: an overview of recent findings.Autoimmune diseases · 2012Article
- Local renal autoantibody production in lupus nephritis.Journal of the American Society of Nephrology : JASN · 2011Article
- The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.Immunity · 2010Article
- Article
- Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus.Lupus · 2009Article
- Interleukin-6 is responsible for aberrant B-cell receptor-mediated regulation of RAG expression in systemic lupus erythematosus.Immunology · 2007Article
- Article
- Subversion of B lymphocyte tolerance by hydralazine, a potential mechanism for drug-induced lupus.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The autoimmune disease systemic lupus erythematosus (SLE) is caused by a failure of B cell tolerance. Recent studies in mouse models of SLE have identified several distinct tolerance checkpoints that must each function appropriately to protect against disease. However, studies of B cell repertoire selection in humans are essential to understand which checkpoints are defective in human autoimmune diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.