ReviewThorax2005
Focus on antioxidant enzymes and antioxidant strategies in smoking related airway diseases.
Review in Thorax, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 121 citations in OpenAlex.
- Brain-derived neurotrophic factor in cigarette smoke-induced airway hyperreactivity.American journal of respiratory cell and molecular biology · 2013Trial
- Nicotine-free electronic vape fluid stimulates angiogenic processesFrontiers in toxicology · 2025Article
- Association between cigarette smoking and the prevalence of post-endodontic periapical pathology: a systematic review and meta-analysis.Restorative dentistry & endodontics · 2022Article
- Loading of Beclomethasone in Liposomes and Hyalurosomes Improved with Mucin as Effective Approach to Counteract the Oxidative Stress Generated by Cigarette Smoke Extract.Nanomaterials (Basel, Switzerland) · 2021Article
- Effects of Anacardic Acid Monoene on the Respiratory System of Mice Submitted to Acute Respiratory Distress Syndrome.Revista brasileira de farmacognosia : orgao oficial da Sociedade Brasileira de Farmacognosia · 2021Article
- Correlation between serum transforming growth factor β1, interleukin-6 and neonatal respiratory distress syndrome.Experimental and therapeutic medicine · 2019Article
- Fertility hormones and vitamin E in active and passive adult male smokers in Calabar, Nigeria.PloS one · 2018Article
- Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages.American journal of respiratory and critical care medicine · 2017Article
- Article
- (-)-Epigallocatechin-3-gallate Reduces Cigarette Smoke-Induced Airway Neutrophilic Inflammation and Mucin Hypersecretion in Rats.Frontiers in pharmacology · 2017Article
- Role of oxidative stress and outcome of various surgical approaches among patients with bullous lung disease candidate for surgical interference.Journal of thoracic disease · 2016Article
- Aging-Related Decline of Glutathione Peroxidase 3 and Risk of Cardiovascular Events in Patients With Atrial Fibrillation.Journal of the American Heart Association · 2016Article
- Glutathione peroxidase 3 localizes to the epithelial lining fluid and the extracellular matrix in interstitial lung disease.Scientific reports · 2016Article
- Association of serum ferritin levels with smoking and lung function in the Korean adult population: analysis of the fourth and fifth Korean National Health and Nutrition Examination Survey.International journal of chronic obstructive pulmonary disease · 2016Article
- Relationship between plasma matrix metalloproteinase levels, pulmonary function, bronchodilator response, and emphysema severity.International journal of chronic obstructive pulmonary disease · 2016Article
- SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Oxidative stress-mediated iNKT-cell activation is involved in COPD pathogenesis.Mucosal immunology · 2014Article
- Large-scale, ion-current-based proteomics investigation of bronchoalveolar lavage fluid in chronic obstructive pulmonary disease patients.Journal of proteome research · 2014Article
- Smoke extract impairs adenosine wound healing: implications of smoke-generated reactive oxygen species.American journal of respiratory cell and molecular biology · 2013Article
- Biomarkers in Exhaled Breath Condensate and Serum of Chronic Obstructive Pulmonary Disease and Non-Small-Cell Lung Cancer.International journal of chronic diseases · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cigarette smoke causes significant oxidant stress which is further enhanced by recruitment and activation of inflammatory cells to the lung. Polymorphisms in some detoxification enzymes are thought to increase the risk of developing chronic obstructive pulmonary disease (COPD), but the ultimate role of genetic variability in antioxidant and/or detoxification enzymes in COPD remains obscure. Some antioxidant enzymes are inducted, but the extent of induction is insufficient to protect the lung/alveolar epithelium against cigarette smoke. Exogenous antioxidants such as vitamins do not seem to protect against cigarette smoke related lung injury. Glutathione related synthetic drugs such as N-acetylcysteine have shown some benefits, but they may have pro-oxidant side effects. Synthetic compounds with superoxide dismutase and catalase activities have shown promising results in animal models against a variety of oxidant exposures including cigarette smoke in the lung. These results are in agreement with studies highlighting the importance of alveolar antioxidant protection mechanisms in oxidant stress and their inducibility. These new drugs need to be tested in cigarette smoking related lung injury/inflammation since inflammation/oxidant stress can continue after discontinuation of smoking.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.