ArticleThorax2005
Genotypic variation in Pneumocystis jirovecii isolates in Britain.
Article in Thorax, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 51 citations in OpenAlex.
- Multilocus Genotyping ofJournal of fungi (Basel, Switzerland) · 2021Article
- Pneumocystis pneumonia in liver transplant recipients.American journal of translational research · 2021Article
- Circulating genotypes of Pneumocystis jirovecii and its clinical correlation in patients from a single tertiary center in India.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Review
- Pneumocystis jirovecii Pneumonia in Rheumatoid Arthritis Patients: Risks and Prophylaxis Recommendations.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2015Review
- Prevalence and genotype distribution of Pneumocystis jirovecii in Cuban infants and toddlers with whooping cough.Journal of clinical microbiology · 2014Article
- Prospective multicenter study of Pneumocystis jirovecii colonization among cystic fibrosis patients in France.Journal of clinical microbiology · 2012Article
- Pneumocystis jirovecii infection: an emerging threat to patients with rheumatoid arthritis.Rheumatology (Oxford, England) · 2012Review
- Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia.Diagnostic microbiology and infectious disease · 2012Article
- Clinical relevance of multiple single-nucleotide polymorphisms in Pneumocystis jirovecii Pneumonia: development of a multiplex PCR-single-base-extension methodology.Journal of clinical microbiology · 2011Article
- Clinical characteristics of Pneumocystis pneumonia in non-HIV patients and prognostic factors including microbiological genotypes.BMC infectious diseases · 2011Article
- Clinical significance and phylogenetic relationship of novel Australian Pneumocystis jirovecii genotypes.Journal of clinical microbiology · 2009Article
- Cavitary pulmonary disease.Clinical microbiology reviews · 2008Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPneumocystis jirovecii is the cause of Pneumocystis pneumonia (PCP) in immunosuppressed humans. Asymptomatic colonisation with P jirovecii may occur in patients with minor immunosuppression or chronic lung disease. The aim of this study was to describe the molecular epidemiology of P jirovecii in Britain over a period of 12.5 years.
methodsBetween January 1989 and July 2001 161 samples of P jirovecii were obtained from patients with PCP (n = 119), patients colonised by P jirovecii (n = 35), and from air spora (n = 6). Genotyping of samples was performed at the mitochondrial large subunit rRNA (mt LSU rRNA).
resultsGenotype 1 (38%) was the most frequently identified genotype: genotypes 2 (26.6%), 3 (20.3%), and 4 (5%) were less common. Mixed infection (more than one genotype) was identified in 10% of samples. While genotype 1 was the most frequently detected type in both patients with PCP and those colonised by P jirovecii (38% and 42%, respectively), these groups differed in the relatively lower rate of detection of genotype 4 (2% v 17%) and the higher detection of mixed infection in those with PCP (13% v 3%). Detection of specific genotypes of P jirovecii was associated with the patient's place of residence (p = 0.02). There was no association between specific genotypes and severity of PCP as measured by arterial oxygen tension (p = 0.3).
conclusionsThe evidence of clustering of specific genotypes with patient's postcode of residence is consistent with the hypothesis of person to person transmission of P jirovecii via the airborne route. The lack of association between specific mt LSU rRNA genotypes and severity of PCP suggests that this locus is not implicated in the virulence of the organism.
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