ArticleThorax2005
A novel tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphism associated with asthma in Australian women.
Article in Thorax, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Association of Matrix Metalloproteinase 9 (Canadian respiratory journal · 2019Pooled it
- Eosinophil extracellular traps in asthma: implications for pathogenesis and therapy.Respiratory research · 2023Review
- Application of weighted gene co-expression network and immune infiltration for explorations of key genes in the brain of elderly COVID-19 patients.Frontiers in immunology · 2023Article
- Exploring a possible association between the occurrence of theBiochemistry and biophysics reports · 2021Article
- Quantum Dot Based Nano-Biosensors for Detection of Circulating Cell Free miRNAs in Lung Carcinogenesis: From Biology to Clinical Translation.Frontiers in genetics · 2018Review
- Matrix Metalloproteinase-9 (279R/Q) Polymorphism is Associated with Clinical Severity and Airflow Limitation in Tunisian Patients with Chronic Obstructive Pulmonary Disease.Molecular diagnosis & therapy · 2015Article
- The 372 T/C genetic polymorphism of TIMP-1 is associated with serum levels of TIMP-1 and survival in patients with severe sepsis.Critical care (London, England) · 2013Observational
- The α(1)AT and TIMP-1 Gene Polymorphism in the Development of Asthma.Comparative and functional genomics · 2012Article
- The selected genetic polymorphisms of metalloproteinases MMP2, 7, 9 and MMP inhibitor TIMP2 in sarcoidosis.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
- Genetic variation in TIMP1 but not MMPs predict excess FEV1 decline in two general population-based cohorts.Respiratory research · 2011Article
- Tissue inhibitor of matrix-metalloprotease-1 predicts risk of hepatic fibrosis in human Schistosoma japonicum infection.The Journal of infectious diseases · 2011Article
- MMP9 modulates tight junction integrity and cell viability in human airway epithelia.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Tissue inhibitor of metalloproteinase-1 modulates allergic lung inflammation in murine asthma.Clinical immunology (Orlando, Fla.) · 2009Article
- DNA sequence variations of metalloproteinases: their role in asthma and COPD.Postgraduate medical journal · 2007Review
- Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted.Physiological reviews · 2007Review
- Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer.British journal of cancer · 2006Article
- Susceptibility genes in severe asthma.Current allergy and asthma reports · 2006Review
- Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan.In vivo (Athens, Greece)Article
- Impacts of Matrix Metalloproteinase-9 Promoter Genotypes on Asthma Risk.In vivo (Athens, Greece)Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAirway remodelling is a characteristic feature of chronic asthma and there is evidence that an airway imbalance between levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) is associated with airway remodelling. On this basis, we hypothesised that polymorphisms in the MMP-9 and TIMP-1 genes were associated with the disease process.
methodsA number of MMP-9 and TIMP-1 gene polymorphisms were examined in an adult white Australian population of mild (n = 259), moderate (n = 213) and severe (n = 71) asthmatics and non-asthmatic controls (n = 406) using PCR-RFLP and PCR-SSCP analyses.
resultsMMP-9 -1562C>T and 836G>A (Arg279Gln) were not associated with asthma (p> or =0.15) or asthma severity (p> or =0.13), and TIMP-1 434T>C (Phe124Phe) was not associated with asthma in women (p = 0.094) or men (p = 0.207). In this population, MMP-9 -861C>T and TIMP-1 323C>T (Pro87Pro) were not informative (with minor allele frequencies of <1%), and MMP-9 -1702T>A and TIMP-1 595C>T (Ser178Phe) were not detectable. However, a novel polymorphism was detected in the TIMP-1 gene 536C>T (Ile158Ile) which was significantly associated with asthma in women (p = 0.011; OR = 5.54, 95% CI 1.66 to 34.4) but not in men (p = 1.0). 536C>T was found to be in linkage disequilibrium with 434T>C, and haplotype analysis supported an association with asthma (p = 0.014).
conclusionsThis is the first reported association between a polymorphism in the TIMP-1 gene and asthma, and supports the hypothesis that the protease/antiprotease balance has an important role in this common disease.
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