ReviewSeminars in reproductive medicine2005
Oocyte maturation: the coming of age of a germ cell.
Review in Seminars in reproductive medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 121 citations in OpenAlex.
- In vitro maturation 2.0: a new era for an underdog in ART.JBRA assisted reproduction · 2026Review
- Optimizing Rat In Vitro Fertilization for Rat Model Cryo-Resuscitation from Frozen-Thawed Sperm.Biology · 2026Article
- Sex-specific functional evolution of Dmrt1 in African clawed frogs (Xenopus), and the importance of genetic tipping points in developmental biology.PLoS genetics · 2026Article
- The role of omentin-1 in female reproduction: a critical review.The Journal of reproduction and development · 2026Review
- CCNA2 and CCNB3 as Early Potential Molecular Candidates of Oocyte Maturation in Cumulus-Oophorous Complex Cells from Follicular Fluid.Diagnostics (Basel, Switzerland) · 2025Article
- Vitellogenin receptor mediates heat adaptability of oocyte development in mud crabs and zebrafish.Nature communications · 2025Article
- Investigation of FF-MAS oxysterole's role in follicular development and its relation to hedgehog signal pathway.Scientific reports · 2024Article
- Mature oocyte dysmorphisms may be associated with progesterone levels, mitochondrial DNA content, and vitality in luteal granulosa cells.Journal of assisted reproduction and genetics · 2024Article
- A comprehensive review on the impact of calcium and vitamin D insufficiency and allied metabolic disorders in females.Food science & nutrition · 2023Review
- The spectrum ofFrontiers in endocrinology · 2023Review
- Investigation of Signals and Transcription Factors for The Generation of Female Germ-Like Cells.Cell journal · 2022Article
- Multigenerational Effects of an Environmentally Relevant Phthalate Mixture on Reproductive Parameters and Ovarian miRNA Expression in Female Rats.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- Glutathione deficiency decreases lipid droplet stores and increases reactive oxygen species in mouse oocytes†.Biology of reproduction · 2022Article
- Oocyte maturation abnormalities - A systematic review of the evidence and mechanisms in a rare but difficult to manage fertility pheneomina.Turkish journal of obstetrics and gynecology · 2022Article
- Glucocorticoids, Stress and Delta-9 Tetrahydrocannabinol (THC) during Early Embryonic Development.International journal of molecular sciences · 2021Review
- Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers.International journal of molecular sciences · 2021Review
- Toxicant effects on mammalian oocyte mitochondria†.Biology of reproduction · 2021Review
- Oocyte Competence Biomarkers Associated With Oocyte Maturation: A Review.Frontiers in cell and developmental biology · 2021Review
- Fertility Options for the Transgender and Gender Nonbinary Patient.The Journal of clinical endocrinology and metabolism · 2020Review
- Transgender Men and the Gynecologist.Clinical obstetrics and gynecology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Normal female fertility relies on proper development of the oocyte. This growth culminates just prior to ovulation, when oocyte maturation occurs. Oocyte maturation refers to a release of meiotic arrest that allows oocytes to advance from prophase I to metaphase II of meiosis. This precisely regulated meiotic progression is essential for normal ovulation and subsequent fertilization, and involves changes in the delicate balance between factors promoting meiotic arrest and others that are stimulating maturation. Most of the inhibitory mechanisms appear to involve the upregulation of intracellular cyclic adenosine monophosphate levels. These processes may include direct transport of the nucleotide into oocytes via gap junctions, G protein-mediated stimulation of adenylyl cyclase, and inhibition of intracellular phosphodiesterases. In contrast, potential factors that play roles in triggering oocyte maturation include gonadotropins (e.g., follicle-stimulating factor and luteinizing hormone), growth factors (e.g., amphiregulin and epiregulin), sterols (e.g., follicular fluid-derived meiosis-activating sterol), and steroids (e.g., testosterone progesterone, and estradiol). Delineating the complex interactions between these positive and negative components is critical for determining the role that oocyte maturation plays in regulating follicle development and ovulation, and may lead to novel methods that can be used to modulate these processes in women with both normal and aberrant fertility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.