ArticleJournal of molecular evolution2005
"Word" preference in the genomic text and genome evolution: different modes of n-tuplet usage in coding and noncoding sequences.
Article in Journal of molecular evolution, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Information theory applications for biological sequence analysis.Briefings in bioinformatics · 2014Review
- Diminishing return for increased Mappability with longer sequencing reads: implications of the k-mer distributions in the human genome.BMC bioinformatics · 2014Article
- The evolution of word composition in metazoan promoter sequence.PLoS computational biology · 2006Article
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2 authors.
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Abstract
Extensive work on n-tuplet occurrence in genomic sequences has revealed the correlation of their usage with sequence origin. Parallel to that, there exist different restrictions in the nucleotide composition of coding and noncoding sequences that may result in distinct modes of usage of n-tuplets. The relatively simple approaches described herein focus on such differences. They are based on simple summation measures of n-tuplet frequencies, computed after filtering the background nucleotide composition. Among the main targets of this work is to draw some conclusions on the qualitative differences in the composition of genomic sequences depending on their functionality. Moreover, an evolutionary model is formulated, including simple forms of ubiquitous events of genome dynamics: genomic fusions, genome shuffling due to transpositions, replication slippage, and point mutations. This model is shown to be able to reproduce all the statistical features of genomic sequences discussed herein.
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