ArticleJournal of molecular evolution2005
Evolution of the genetic triplet code via two types of doublet codons.
Article in Journal of molecular evolution, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Avoiding Catastrophic Mutations Accurately Predicts Amino Acid to Codon Pairing.Journal of molecular evolution · 2026Article
- On the Origin of Frameshift-Robustness of the Standard Genetic Code.Molecular biology and evolution · 2021Article
- Circular Tessera Codes in the Evolution of the Genetic Code.Bulletin of mathematical biology · 2020Article
- Evolution of complete proteomes: guanine-cytosine pressure, phylogeny and environmental influences blend the proteomic architecture.BMC evolutionary biology · 2013Article
- On the organizational dynamics of the genetic code.Genomics, proteomics & bioinformatics · 2011Article
- Exceptional error minimization in putative primordial genetic codes.Biology direct · 2009Article
- Article
- Origin and evolution of the genetic code: the universal enigma.IUBMB life · 2009Review
- A model for the origin of protein synthesis as coreplicational scanning of nascent RNA.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2007Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Explaining the apparent non-random codon distribution and the nature and number of amino acids in the 'standard' genetic code remains a challenge, despite the various hypotheses so far proposed. In this paper we propose a simple new hypothesis for code evolution involving a progression from singlet to doublet to triplet codons with a reading mechanism that moves three bases each step. We suggest that triplet codons gradually evolved from two types of ambiguous doublet codons, those in which the first two bases of each three-base window were read ('prefix' codons) and those in which the last two bases of each window were read ('suffix' codons). This hypothesis explains multiple features of the genetic code such as the origin of the pattern of four-fold degenerate and two-fold degenerate triplet codons, the origin of its error minimising properties, and why there are only 20 amino acids.
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Identifiers
16059752What OpenQuestion holds
Registered trials
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