ArticleEpilepsy currents
Group I mGluR-induced epileptogenesis: distinct and overlapping roles of mGluR1 and mGluR5 and implications for antiepileptic drug design.
Article in Epilepsy currents. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Morphometric Similarity Loss and Gray Matter Atrophy Align with Neurotransmitter and Mitochondrial Maps in Drug-Resistant Epilepsy.Neuropsychiatric disease and treatment · 2026Article
- Epilepsy Characteristics in Neurodevelopmental Disorders: Research from Patient Cohorts and Animal Models Focusing on Autism Spectrum Disorder.International journal of molecular sciences · 2022Review
- G protein-coupled receptors in acquired epilepsy: Druggability and translatability.Progress in neurobiology · 2019Review
- Expression of mGlu Receptor Genes in the Hippocampus After Intoxication with Trimethyltin.Journal of molecular neuroscience : MN · 2019Article
- Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors.Frontiers in molecular neuroscience · 2018Review
- Mechanisms of tau and Aβ-induced excitotoxicity.Brain research · 2016Article
- Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics.Journal of medicinal chemistry · 2015Article
- Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics.Current opinion in pharmacology · 2015Review
- Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Nature reviews. Drug discovery · 2014Review
- Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254).Journal of medicinal chemistry · 2013Article
- Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism.Drug metabolism and disposition: the biological fate of chemicals · 2013Article
- Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.Biological psychiatry · 2013Article
- Metabotropic glutamate receptors as therapeutic targets for schizophrenia.Neuropharmacology · 2012Review
- Beyond dopamine: glutamate as a target for future antipsychotics.ISRN pharmacology · 2012Article
- Targeting glutamate synapses in schizophrenia.Trends in molecular medicine · 2011Review
- High-frequency network activity, global increase in neuronal activity, and synchrony expansion precede epileptic seizures in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Article
- Effects of subtype-selective group I mGluR antagonists on synchronous activity induced by 4-aminopyridine/CGP 55845 in adult guinea pig hippocampal slices.Neuropharmacology · 2008Article
- Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-catenin during oxidative stress.Current neurovascular research · 2006Article
- Driving cellular plasticity and survival through the signal transduction pathways of metabotropic glutamate receptors.Current neurovascular research · 2005Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The group I metabotropic glutamate receptor subtypes, mGluR1 and mGluR5, have both distinct and overlapping actions in epileptogenesis. Data are reviewed revealing how activation of these receptor subtypes participates in the induction and maintenance of the long-lasting epileptiform discharges elicited in the hippocampal circuit. Differences in the cellular actions and regional distributions of mGluR1 and mGluR5 provide hints regarding the potential usefulness and limitations of subtype-specific antagonists as antiepileptic agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.