ArticleMolecular and cellular biology2005
The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Heat tolerance inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Systemic changes in cell size throughout the body of Drosophila melanogaster associated with mutations in molecular cell cycle regulators.Scientific reports · 2023Article
- Review
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- Muscle-derived Dpp regulates feeding initiation via endocrine modulation of brain dopamine biosynthesis.Genes & development · 2020Article
- Hippo Signaling in Cancer: Lessons FromFrontiers in cell and developmental biology · 2019Review
- The genetic basis for variation in resistance to infection in the Drosophila melanogaster genetic reference panel.PLoS pathogens · 2017Article
- Article
- MNT and Emerging Concepts of MNT-MYC Antagonism.Genes · 2017Article
- Inhibition of Daughterless by Extramacrochaetae mediates Notch-induced cell proliferation.Development (Cambridge, England) · 2015Article
- Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.Biochimica et biophysica acta · 2015Review
- Drosophila Myc: A master regulator of cellular performance.Biochimica et biophysica acta · 2015Review
- Taming of the beast: shaping Myc-dependent amplification.Trends in cell biology · 2015Review
- Growing old with Myc.Cell · 2015Article
- Article
- Article
- An overview of MYC and its interactome.Cold Spring Harbor perspectives in medicine · 2014Review
- Myc function in Drosophila.Cold Spring Harbor perspectives in medicine · 2013Review
- Distinct mechanisms of transcriptional pausing orchestrated by GAGA factor and M1BP, a novel transcription factor.The EMBO journal · 2013Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The Myc-Max-Mad/Mnt network of transcription factors has been implicated in oncogenesis and the regulation of proliferation in vertebrate cells. The identification of Myc and Max homologs in Drosophila melanogaster has demonstrated a critical role for dMyc in cell growth control. In this report, we identify and characterize the third member of this network, dMnt, the sole fly homolog of the mammalian Mnt and Mad family of transcriptional repressors. dMnt possesses two regions characteristic of Mad and Mnt proteins: a basic helix-loop-helix-zipper domain, through which it dimerizes with dMax to form a sequence-specific DNA binding complex, and a Sin-interacting domain, which mediates interaction with the dSin3 corepressor. Using the upstream activation sequence/GAL4 system, we show that expression of dMnt results in an inhibition of cellular growth and proliferation. Furthermore, we have generated a dMnt null allele, which results in flies with larger cells, increased weight, and decreased life span compared to wild-type flies. Our results demonstrate that dMnt is a transcriptional repressor that regulates D. melanogaster body size.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.