ArticleAmerican journal of respiratory cell and molecular biology2005
Alternate paths from epidermal growth factor receptor to Akt in malignant versus nontransformed lung epithelial cells: ErbB3 versus Gab1.
Article in American journal of respiratory cell and molecular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Glycogen Metabolism Predicts the Efficacy of Immunotherapy for Urothelial Carcinoma.Frontiers in pharmacology · 2021Article
- HER2 Amplification in Tumors Activates PI3K/Akt Signaling Independent of HER3.Cancer research · 2018Article
- Transcriptionally inducible Pleckstrin homology-like domain, family A, member 1, attenuates ErbB receptor activity by inhibiting receptor oligomerization.The Journal of biological chemistry · 2018Article
- ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas.Cancer research · 2015Article
- Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth.Prostaglandins, leukotrienes, and essential fatty acids · 2014Article
- Constitutive androstane receptor ligands modulate the anti-tumor efficacy of paclitaxel in non-small cell lung cancer cells.PloS one · 2014Article
- Curcumin and vitamin E protect against adverse effects of benzo[a]pyrene in lung epithelial cells.PloS one · 2014Article
- Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants.The Journal of biological chemistry · 2013Article
- Stabilization of ribozyme-like cis-noncoding rRNAs induces apoptotic and nonapoptotic death in lung cells.Cell death & disease · 2012Article
- Anti-tumor efficacy of naked siRNAs for ERBB3 or AKT2 against lung adenocarcinoma cell xenografts.International journal of cancer · 2012Article
- Molecular effects of doxycycline treatment on pterygium as revealed by massive transcriptome sequencing.PloS one · 2012Article
- Non-coding rRNA-mediated preferential killing in cancer cells is enhanced by suppression of autophagy in non-transformed counterpart.Cell death & disease · 2011Article
- RNA interference against hepatic epidermal growth factor receptor has suppressive effects on liver regeneration in rats.The American journal of pathology · 2010Article
- Biphasic regulation of ENaC by TGF-{alpha} and EGF in renal epithelial cells.American journal of physiology. Renal physiology · 2009Article
- The ERBB3 receptor in cancer and cancer gene therapy.Cancer gene therapy · 2008Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In many human lung adenocarcinoma cell lines, a pathway involving epidermal growth factor receptor (EGFR), ErbB2 and ErbB3 receptors, phosphatidyl inositol 3-kinase (PI3K), Akt, glycogen synthase kinase 3-beta (GSK3-beta), and cyclin D1 controls cell growth, survival, and invasiveness. We have investigated this pathway in paired transformed/nontransformed cell lines from murine peripheral lung epithelium, E9/E10 and A5/C10. The E9 and A5 carcinoma lines expressed ErbB3 and transforming growth factor-alpha (TGF-alpha) and responded to TGF-alpha stimulation with protein complex formation including the p85 regulatory subunit of PI3K, activation of Akt, phosphorylation of GSK3-beta, and increased cyclin D1 protein and the cell cycle. ErbB3 and TGF-alpha were not detected in the nontransformed E10 and C10 cell lines. Nevertheless, exposure of E10 or C10 cells to TGF-alpha activated PI3K and Akt and increased cyclin D1 and cell growth. The effector pathway from the EGFR to PI3K in these nontransformed cells included the adaptor Grb2, the docking protein Gab1, and the phosphatase Shp2. Gab1 was highly expressed in E10 and C10 cells but not in the malignant E9 and A5 sister lines. Complexes of EGFR/Grb2/Gab1/Shp2 after TGF-alpha stimulation were prominent only in E10 and C10 cells. Thus, alternate pathways downstream of EGFR regulate mitosis in these paired malignant versus nontransformed lung cell lines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.