ArticleProceedings of the National Academy of Sciences of the United States of America2005
Cationic liposome-microtubule complexes: pathways to the formation of two-state lipid-protein nanotubes with open or closed ends.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Lipid-Nucleic Acid Complexes: Physicochemical Aspects and Prospects for Cancer Treatment.Molecules (Basel, Switzerland) · 2020Review
- Minireview - Microtubules and Tubulin Oligomers: Shape Transitions and Assembly by Intrinsically Disordered Protein Tau and Cationic Biomolecules.Langmuir : the ACS journal of surfaces and colloids · 2019Review
- Artificial Cell Membranes Interfaced with Optical Tweezers: A Versatile Microfluidics Platform for Nanomanipulation and Mechanical Characterization.ACS applied materials & interfaces · 2019Article
- What can machine learning do for antimicrobial peptides, and what can antimicrobial peptides do for machine learning?Interface focus · 2017Review
- Article
- The effect of multivalent cations and Tau on paclitaxel-stabilized microtubule assembly, disassembly, and structure.Advances in colloid and interface science · 2016Review
- A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes.Advances in colloid and interface science · 2016Review
- Direct force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Transformation of taxol-stabilized microtubules into inverted tubulin tubules triggered by a tubulin conformation switch.Nature materials · 2014Article
- Effect of capsid confinement on the chromatin organization of the SV40 minichromosome.Nucleic acids research · 2013Article
- Ion specific effects in bundling and depolymerization of taxol-stabilized microtubules.Faraday discussions · 2013Article
- Nanoscale assembly in biological systems: from neuronal cytoskeletal proteins to curvature stabilizing lipids.Advanced materials (Deerfield Beach, Fla.) · 2011Review
- Architectonics of phage-liposome nanowebs as optimized photosensitizer vehicles for photodynamic cancer therapy.Molecular cancer therapeutics · 2010Article
- Nonlinearities in tilt and layer displacements of planar lipid bilayers.The European physical journal. E, Soft matter · 2010Article
- Human microtubule-associated-protein tau regulates the number of protofilaments in microtubules: a synchrotron x-ray scattering study.Biophysical journal · 2009Article
- The multiple faces of self-assembled lipidic systems.PMC biophysics · 2009Article
- Block liposomes from curvature-stabilizing lipids: connected nanotubes, -rods, or -spheres.Langmuir : the ACS journal of surfaces and colloids · 2009Article
- Block liposomes vesicles of charged lipids with distinctly shaped nanoscale sphere-, pear-, tube-, or rod-segments.Methods in enzymology · 2009Article
- In vitro self-assembly of tailorable nanotubes from a simple protein building block.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Microtubule protofilament number is modulated in a stepwise fashion by the charge density of an enveloping layer.Biophysical journal · 2007Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Intermolecular interactions between charged membranes and biological polyelectrolytes, tuned by physical parameters, which include the membrane charge density and bending rigidity, the membrane spontaneous curvature, the biopolymer curvature, and the overall charge of the complex, lead to distinct structures and morphologies. The self-assembly of cationic liposome-microtubule (MT) complexes was studied, using synchrotron x-ray scattering and electron microscopy. Vesicles were found to either adsorb onto MTs, forming a "beads on a rod" structure, or undergo a wetting transition and coating the MT. Tubulin oligomers then coat the external lipid layer, forming a tunable lipid-protein nanotube. The beads on a rod structure is a kinetically trapped state. The energy barrier between the states depends on the membrane bending rigidity and charge density. By controlling the cationic lipid/tubulin stoichiometry it is possible to switch between two states of nanotubes with either open ends or closed ends with lipid caps, a process that forms the basis for controlled chemical and drug encapsulation and release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.