ArticleBiophysical journal2005
A quantitative model of purinergic junctional transmission of calcium waves in astrocyte networks.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 98 citations in OpenAlex.
- Analysis of Network Models with Neuron-Astrocyte Interactions.Neuroinformatics · 2023Article
- Amyloid pathology disrupts gliotransmitter release in astrocytes.PLoS computational biology · 2022Article
- Article
- Quantifying the dose-dependent impact of intracellular amyloid beta in a mathematical model of calcium regulation in xenopus oocyte.PloS one · 2021Article
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- Coronary Smooth Muscle Cell Calcium Dynamics: Effects of Bifurcation Angle on Atheroprone Conditions.Frontiers in physiology · 2018Article
- 3D time-varying simulations of CaInternational journal for numerical methods in biomedical engineering · 2017Article
- Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities.Frontiers in physiology · 2017Review
- Mast cell-nerve cell interaction at acupoint: modeling mechanotransduction pathway induced by acupuncture.International journal of biological sciences · 2014Article
- A positive feedback cell signaling nucleation model of astrocyte dynamics.Frontiers in neuroengineering · 2013Article
- Intercellular Ca(2+) waves: mechanisms and function.Physiological reviews · 2012Review
- IFN-γ-induced increase in the mobility of MHC class II compartments in astrocytes depends on intermediate filaments.Journal of neuroinflammation · 2012Article
- Article
- Astrocytes in Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2010Review
- Mapping the spatiotemporal dynamics of calcium signaling in cellular neural networks using optical flow.Annals of biomedical engineering · 2010Article
- Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks.Journal of biological physics · 2009Article
- A quantitative model of cortical spreading depression due to purinergic and gap-junction transmission in astrocyte networks.Biophysical journal · 2008Article
- ATP signalling in epilepsy.Purinergic signalling · 2008Article
- Purinergic junctional transmission and propagation of calcium waves in cultured spinal cord microglial networks.Purinergic signalling · 2008Article
- Diffusion modeling of ATP signaling suggests a partially regenerative mechanism underlies astrocyte intercellular calcium waves.Frontiers in neuroengineering · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A principal means of transmitting intracellular calcium (Ca2+) waves at junctions between astrocytes involves the release of the chemical transmitter adenosine triphosphate (ATP). A model of this process is presented in which activation of purinergic P2Y receptors by ATP triggers the release of ATP, in an autocrine manner, as well as concomitantly increasing intracellular Ca2+. The dependence of the temporal characteristics of the Ca2+ wave are shown to critically depend on the dissociation constant (K(R)) for ATP binding to the P2Y receptor type. Incorporating this model astrocyte into networks of these cells successfully accounts for many of the properties of propagating Ca2+ waves, such as the dependence of velocity on the type of P2Y receptor and the time-lag of the Ca2+ wave behind the ATP wave. In addition, the conditions under which Ca2+ waves may jump from one set of astrocytes across an astrocyte-free lane to another set of astrocytes are quantitatively accounted for by the model. The properties of purinergic transmission at astrocyte junctions may determine many of the characteristics of Ca2+ propagation in networks of these cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.