ArticleInternational journal of pharmaceutics2005
Stability of dexamethasone sodium phosphate in rat plasma.
Article in International journal of pharmaceutics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Across-species meta-analysis of dexamethasone pharmacokinetics utilizing allometric and scaling modeling approaches.Biopharmaceutics & drug disposition · 2021Pooled it
- Bimodal Dissolving Microneedles with Nanoparticle Coating and Encapsulation for Extended Dual-Drug Delivery.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs.Frontiers in pharmacology · 2024Article
- Betulin and Its Derivatives Reduce Inflammation and COX-2 Activity in Macrophages.Inflammation · 2023Article
- Six-month effective treatment of corneal graft rejection.Science advances · 2023Article
- Ocular prodrugs: Attributes and challenges.Asian journal of pharmaceutical sciences · 2021Review
- Epigenetic alterations associated with dexamethasone sodium phosphate through DNMT and TET in RPE cells.Molecular vision · 2021Article
- Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches.Cellular & molecular immunology · 2017Review
- Pharmacokinetics of dexamethasone in a rat model of rheumatoid arthritis.Biopharmaceutics & drug disposition · 2008Article
- Modeling corticosteroid effects in a rat model of rheumatoid arthritis I: mechanistic disease progression model for the time course of collagen-induced arthritis in Lewis rats.The Journal of pharmacology and experimental therapeutics · 2008Article
- Modeling corticosteroid effects in a rat model of rheumatoid arthritis II: mechanistic pharmacodynamic model for dexamethasone effects in Lewis rats with collagen-induced arthritis.The Journal of pharmacology and experimental therapeutics · 2008Article
- Risk of death does not alter the efficacy of hydrocortisone therapy in a mouse E. coli pneumonia model: risk and corticosteroids in sepsis.Intensive care medicine · 2008Article
- Pharmacokinetics of methylprednisolone after intravenous and intramuscular administration in rats.Biopharmaceutics & drug disposition · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The use of corticosteroid prodrugs in pharmacokinetic studies poses the risk of overestimation of corticosteroid concentrations due to in vitro hydrolysis of prodrugs after sample collection. This study tests the effectiveness of the anticoagulant EDTA as a stabilizer for dexamethasone sodium phosphate (DSP) in rat plasma and provides simultaneous HPLC analysis of DSP and dexamethasone. An already developed ion-paired reversed-phase HPLC assay for simultaneous measurement of corticosteroid phosphate ester prodrugs and their active steroids was applied in this study. This assay was used for analyzing samples from an in vitro DSP hydrolysis study in rat plasma. In agreement with allometric principles, the prodrug hydrolysis occurred at a much faster rate (in vitro half-life of 1.75 h) in rat plasma as compared with previously reported prodrug hydrolysis half-life of 10-12 h in sheep and human plasma. The in vitro degradation of the prodrug in rat plasma was greatly minimized in plasma containing EDTA at the concentration commonly used an anticoagulant. This study demonstrates that artifacts in pharmacokinetic profiles of corticosteroids due to in vitro prodrug hydrolysis can be greatly minimized by collecting blood samples with EDTA as the anticoagulant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.