ArticleCell metabolism2005
Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine.
Article in Cell metabolism, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 62 citations in OpenAlex.
- Aging regulation by gut microbiota: molecular insights from Caenorhabditis elegans.Biogerontology · 2026Review
- Lysosome-related organelles employ divergent mechanisms to modulate cytosolic zinc homeostasis.PLoS genetics · 2026Article
- Proton signaling links epithelial sensing to neural control of host defense in C. elegans.Nature communications · 2026Article
- Identification of molecular nociceptors in Octopus vulgaris through functional characterisation in Caenorhabditis elegans.Biology open · 2026Article
- A specific folate activates serotonergic neurons to control C. elegans behavior.Nature communications · 2024Article
- Diethylcarbamazine, TRP channels and CaScientific reports · 2022Article
- Stearoyl-CoA desaturases sustain cholinergic excitation and copulatory robustness in metabolically agingiScience · 2022Article
- Article
- TRPM7 channel activity in Jurkat T lymphocytes during magnesium depletion and loading: implications for divalent metal entry and cytotoxicity.Pflugers Archiv : European journal of physiology · 2020Article
- Phylogenetics Identifies Two Eumetazoan TRPM Clades and an Eighth TRP Family, TRP Soromelastatin (TRPS).Molecular biology and evolution · 2020Article
- GTL-1, a Calcium Activated TRPM Channel, Enhances Nociception.Frontiers in pharmacology · 2019Article
- Article
- Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.PLoS genetics · 2016Article
- Natural Variation in plep-1 Causes Male-Male Copulatory Behavior in C. elegans.Current biology : CB · 2015Article
- Permeation, regulation and control of expression of TRP channels by trace metal ions.Pflugers Archiv : European journal of physiology · 2015Review
- Novel Alleles of gon-2, a C. elegans Ortholog of Mammalian TRPM6 and TRPM7, Obtained by Genetic Reversion Screens.PloS one · 2015Article
- TRPM7.Handbook of experimental pharmacology · 2014Review
- Evolutionarily conserved, multitasking TRP channels: lessons from worms and flies.Handbook of experimental pharmacology · 2014Article
- Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model.PLoS genetics · 2013Article
- CATP-6, a C. elegans ortholog of ATP13A2 PARK9, positively regulates GEM-1, an SLC16A transporter.PloS one · 2013Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The transient receptor potential (TRP) channels are implicated in various cellular processes, including sensory signal transduction and electrolyte homeostasis. We show here that the GTL-1 and GON-2 TRPM channels regulate electrolyte homeostasis in the C. elegans intestine. GON-2 is responsible for a large outwardly rectifying current of intestinal cells, and its activity is tightly regulated by intracellular Mg(2+) levels, while GTL-1 mainly contributes to appropriate Mg(2+) responsiveness of the outwardly rectifying current. We also used nickel cytotoxicity to study the function of these channels. Both GON-2 and GTL-1 are necessary for intestinal uptake of nickel, but GTL-1 is continuously active while GON-2 is inactivated at higher Mg(2+) levels. This type of differential regulation of intestinal electrolyte absorption ensures a constant supply of electrolytes through GTL-1, while occasional bursts of GON-2 activity allow rapid return to normal electrolyte concentrations following physiological perturbations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.