ArticleWorld journal of gastroenterology2005
Circulating adhesion molecules in patients with virus-related chronic diseases of the liver.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Causal inference regarding infectious aetiology of chronic conditions: a systematic review.PloS one · 2013Pooled it
- Abnormalities of liver sinusoidal endothelial cells in primary biliary cholangitis.World journal of experimental medicine · 2026Article
- Multivariate protein landscape of host response in hospitalised patients with suspected infection in the emergency department.Nature communications · 2025Article
- Impact of HCV elimination on metabolism markers in people living with HIV.Scientific reports · 2025Article
- Direct-acting antivirals improve endothelial function in patients with chronic hepatitis: a prospective cohort study.Internal and emergency medicine · 2020Article
- Soluble Adhesion Molecules in Patients Coinfected with HIV and HCV: A Predictor of Outcome.PloS one · 2016Article
- Multi-analyte profile analysis of plasma immune proteins: altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection.Brain and behavior · 2014Article
- Monocyte adhesion molecules expression in patients with chronic hepatitis C liver disease.Mediterranean journal of hematology and infectious diseases · 2013Article
- Intrahepatic expression of genes related to metabotropic receptors in chronic hepatitis.World journal of gastroenterology · 2012Article
- Evaluation of endothelial function and subclinical atherosclerosis in association with hepatitis C virus in HIV-infected patients: a cross-sectional study.BMC infectious diseases · 2011Article
- sPECAM-1 and sVCAM-1: Role in Pathogenesis and Diagnosis of Chronic Hepatitis C and Association with Response to Antiviral Therapy.Therapeutic advances in gastroenterology · 2009Article
- Establishment of an enzyme-linked immunosorbent assay system for determining soluble CD96 and its application in the measurement of sCD96 in patients with viral hepatitis B and hepatic cirrhosis.Clinical and experimental immunology · 2009Article
- Effects of thalidomide on the expression of adhesion molecules in rat liver cirrhosis.Mediators of inflammation · 2006Article
- Evaluation of Brown Micro-Algae Synergies With Low DoseDose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimIn the inflammatory state, intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) play a key role in promoting migration of immunological cells from the circulation to target site. Aim of our study was to investigate soluble forms of these molecules in patients with virus-related chronic liver diseases, to assess their behavior in different pathologies and correlation with severity of liver damage.
methodsCirculating ICAM-1 and VCAM-1 were assayed by EIA commercial kits (R and D System Co., Abington, UK) in 23 patients with chronic active hepatitis (CH), 50 subjects affected by liver cirrhosis (LC) and 15 healthy controls comparable for sex and age. In patients, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also detected by autoanalyzer.
resultsLC patients had significantly higher ICAM-1 values than CH patients (38.56+/-7.4 ng/mL vs 20.89+/-6.42 ng/mL; P < 0.001) and these ones had significantly higher values than controls (12.92+/-1.08 ng/mL; P < 0.001). In CH group, ICAM-1 levels were significantly related to inflammatory activity (P = 0.041) and ALT values (r = 0.77; P < 0.05). VCAM-1 values were significantly increased only in LC patients (P < 0.001) and related to severity of liver impairment.
conclusionThese findings suggest that the determination of serum ICAM-1 can be considered as an additional useful marker of hepatocellular necrosis and inflammatory activity in chronic hepatitis, while serum VCAM-1 is an indicator of liver fibrogenesis and severity of disease in cirrhosis.
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