ArticleWorld journal of gastroenterology2005
Antibody to eosinophil cationic protein suppresses dextran sulfate sodium-induced colitis in rats.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Antieosinophil Antibodies Alone or in Combination with Antineutrophil Cytoplasmic Antibodies (ANCA) Detected in Different Autoimmune Conditions.Journal of immunology research · 2023Article
- Outcomes of inflammatory bowel disease in patients with eosinophil-predominant colonic inflammation.BMJ open gastroenterology · 2020Article
- Clinical value of serum eosinophilic cationic protein assessment in children with inflammatory bowel disease.Archives of medical science : AMS · 2014Article
- Activated eosinophils in association with enteric nerves in inflammatory bowel disease.PloS one · 2013Article
- The effect of calendula officinalis in therapy of acetic Acid induced ulcerative colitis in dog as an animal model.Iranian Red Crescent medical journal · 2011Article
- CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling.The American journal of pathology · 2011Article
- CD34 is required for infiltration of eosinophils into the colon and pathology associated with DSS-induced ulcerative colitis.The American journal of pathology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo produce an antibody against rat eosinophil cationic protein (ECP) and to examine the effects of the antibody in rats with dextran sulfate sodium (DSS)-induced colitis.
methodsAn antibody was raised against rat ECP. Rats were treated with 3% DSS in drinking water for 7 d and received the antibody or normal serum. The colons were examined histologically and correlated with clinical symptoms. Immunohistochemistry and Western blot analysis were estimated as a grade of inflammation.
resultsThe ECP antibody stained the activated eosinophils around the injured crypts in the colonic mucosa. Antibody treatment reduced the severity of colonic ulceration and acute clinical symptoms (diarrhea and/or blood-stained stool). Body weight gain was significantly greater and the colon length was significantly longer in anti-ECP-treated rats than in normal serum-treated rats. Expression of ECP in activated eosinophils was associated with the presence of erosions and inflammation. The number of Ki-67-positive cells in the regenerated surface epithelium increased in anti-ECP-treated rats compared with normal serum-treated rats. Western blot analysis revealed reduced expression of macrophage migration inhibitory factor (MIF) in anti-ECP-treated rats.
conclusionOur results indicate that treatment with ECP antibody, improved DSS-induced colitis in rats, possibly by increasing the regenerative activity of the colonic epithelium and downregulation of the immune response, and suggest that anti-ECP may promote intestinal wound healing in patients with ulcerative colitis (UC).
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