ArticleWorld journal of gastroenterology2005
Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- In-Vitro Anticancer and Antioxidant Activities of Eremina desertorum (Forsskal, 1775) Snail Mucin.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Fumonisin BToxins · 2020Article
- Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells.Molecular cancer · 2015Article
- A novel functional interplay between Progesterone Receptor-B and PTEN, via AKT, modulates autophagy in breast cancer cells.Journal of cellular and molecular medicine · 2014Article
- Increased hyaluronan levels in HABP1/p32/gC1qR overexpressing HepG2 cells inhibit autophagic vacuolation regulating tumor potency.PloS one · 2014Article
- EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor.Oncogene · 2010Article
- Tumor suppressor and hepatocellular carcinoma.World journal of gastroenterology · 2008Review
- Molecular Pathogenesis of Hepatitis-B-virus-associated Hepatocellular Carcinoma.Gut and liver · 2007Article
- Current development of mTOR inhibitors as anticancer agents.Nature reviews. Drug discovery · 2006Article
- Chronic hepatitis B in hepatocarcinogenesis.Postgraduate medical journal · 2006Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the regulation of phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene expression in human hepatocellular carcinoma (HCC) cell lines.
methodsThe mRNA and protein levels of PTEN were detected by Northern blot and Western blot in HCC cell lines, respectively. Plasmids containing different fragments of PTEN promoter with Luciferase reporter were constructed and transiently transfected into HCC cell lines to study the promoter activity. DNA analysis and RT-PCR were performed to detect the mutation of PTEN promoter and PTEN cDNA.
resultsEither protein or mRNA levels of PTEN in L02 cells (as a control) were significantly higher than that in HCC cell lines. The profile of PTEN promoter activity in 8 cell lines was closely correlated with levels of PTEN mRNA and PTEN protein. Furthermore, the sequence analysis of 8 cells lines showed no mutation in the region of PTEN promoter and PTEN cDNA.
conclusionPTEN expression is down-regulated in HCC cell lines probably due to loss of activity of PTEN promoter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.