ArticleHistochemistry and cell biology2005
Catecholamine-synthesizing enzymes in the adult and prenatal human testis.
Article in Histochemistry and cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- DAPL1 is activated by Np63 and GRα and regulates lipid metabolism.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Paternal Cocaine Exposure and Its Testicular Legacy: Epigenetic, Physiological, and Intergenerational Consequences.Biology · 2025Review
- Biogenic amines in the testis: sources, receptors and actions.Frontiers in endocrinology · 2024Review
- Expression of the NSE,SP,NFH and DβH in normal and cryptorchid testes of Bactrian camel.Animal reproduction · 2022Article
- RT-qPCR forOncology letters · 2017Article
- Autocrine regulation of ecdysone synthesis by β3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Psychostimulant-Induced Testicular Toxicity in Mice: Evidence of Cocaine and Caffeine Effects on the Local Dopaminergic System.PloS one · 2015Article
- Presence and function of dopamine transporter (DAT) in stallion sperm: dopamine modulates sperm motility and acrosomal integrity.PloS one · 2014Article
- Castration induces Parkinson disease pathologies in young male mice via inducible nitric-oxide synthase.The Journal of biological chemistry · 2013Article
- Targeting of the enhanced green fluorescent protein reporter to adrenergic cells in mice.Molecular biotechnology · 2013Article
- Neuroendocrine cells are present in the domestic fowl ovary.Journal of anatomy · 2013Article
- Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolism.Physiological genomics · 2012Article
- Visualization of Reinke's crystals in normal and cryptorchid testis.Histochemistry and cell biology · 2011Article
- Peptidergic not monoaminergic fibers profusely innervate the young adult human testis.Journal of anatomy · 2009Article
- Beta adrenergic receptors in keratinocytes.Dermatologic clinics · 2007Review
- The histochemistry and cell biology vade mecum: a review of 2005-2006.Histochemistry and cell biology · 2006Review
- The expression of neurotrophins and their receptors in the prenatal and adult human testis: evidence for functions in Leydig cells.Histochemistry and cell biology · 2006Article
- Recent progress in histochemistry and cell biology: the state of the art 2005.Histochemistry and cell biology · 2005Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catecholamines play functional roles in the mature and developing mammalian testis but the cell types responsible for their local synthesis are still controversially discussed. Here, we demonstrate that four enzymes involved in the biosynthesis of catecholamines, namely, tyrosine hydroxylase (TH), aromatic amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine- N-methyltransferase (PNMT), are expressed in Leydig cells of the human testis. Tyrosine hydroxylase, the key enzyme of the biosynthesis of catecholamines, was localized to Leydig cells both at the transcript level (by RT-PCR analyses and by in situ hybridization assays) and at the protein level (by immunoblotting and by immunohistochemistry). The other enzymes were also demonstrated in Leydig cells by RT-PCR and immunohistochemical analyses. The presence of TH, AADC, DBH, and PNMT in human Leydig cells was found, in addition, by immunohistochemical approaches carried out on sections from prenatal human testes. Thus, the present study identifies the Leydig cells as the presumed sites of catecholamine production in both the mature and fetal human testes and further supports the previously recognized neuroendocrine characteristics of this cell type.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.