ArticleAnnals of neurology2005
A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.
Article in Annals of neurology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 68 citations in OpenAlex.
- APP-C31 pathology as a target in neurodegenerative diseases.Journal of biomedical science · 2026Review
- Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery.Proteomics · 2025Review
- Role of Ocrelizumab in modulating gene and microRNA expression in multiple sclerosis.Non-coding RNA research · 2025Article
- A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis.The Journal of biological chemistry · 2016Review
- Exome Sequencing Identifies Pathogenic and Modifier Mutations in a Child With Sporadic Dilated Cardiomyopathy.Journal of the American Heart Association · 2015Article
- The back and forth of axonal injury and repair after stroke.Current opinion in neurology · 2014Review
- Global analysis of S-nitrosylation sites in the wild type (APP) transgenic mouse brain-clues for synaptic pathology.Molecular & cellular proteomics : MCP · 2014Article
- Article
- Emerging bioinformatics approaches for analysis of NGS-derived coding and non-coding RNAs in neurodegenerative diseases.Frontiers in cellular neuroscience · 2014Article
- Axonal transport and neurodegenerative disease: can we see the elephant?Progress in neurobiology · 2012Review
- Protein homeostasis, aging and Alzheimer's disease.Molecular neurobiology · 2012Review
- Proteomic analysis of the presynaptic active zone.Experimental brain research · 2012Review
- Alzheimer's disease models and functional genomics-How many needles are there in the haystack?Frontiers in physiology · 2012Article
- Article
- Article
- Neuroproteomics approaches to decipher neuronal regeneration and degeneration.Molecular & cellular proteomics : MCP · 2010Review
- Proteomics analysis reveals novel components in the detergent-insoluble subproteome in Alzheimer's disease.Journal of proteome research · 2009Article
- Chaperone signalling complexes in Alzheimer's disease.Journal of cellular and molecular medicine · 2009Review
- C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2008Article
- Adherent monomer-misfolded SOD1.PloS one · 2008Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
Several approaches have been used in an effort to identify proteins that interact with beta-amyloid precursor protein (APP). However, few studies have addressed the identification of proteins associated with APP in brain tissue from patients with Alzheimer's disease. We report the results of a pilot proteomic study performed on complexes immunoprecipitated with APP in brain samples of patients with Alzheimer's disease and normal control subjects. The 21 proteins identified could be grouped into five functional classes: molecular chaperones, cytoskeletal and structural proteins, proteins involved in trafficking, adaptors, and enzymes. Among the proteins identified, six had been reported previously as direct, indirect, or genetically inferred APP interactors. The other 15 proteins immunoprecipitated with APP were novel potential partners. We confirmed the APP interaction by Western blotting and coimmunolocalization in brain tissues, for 5 of the 21 interactors. In agreement with previous studies, our results are compatible with an involvement of APP in axonal transport and vesicular trafficking, and with a potential association of APP with cellular protein folding/protein degradation systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.