ArticleJournal of psychiatry & neuroscience : JPN2005
Evidence for the activity of lamotrigine at 5-HT(1A) receptors in the mouse forced swimming test.
Article in Journal of psychiatry & neuroscience : JPN, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Drugs with glutamate-based mechanisms of action in psychiatry.Pharmacological reports : PR · 2024Review
- Acute and chronic effects of oral administration of a medium-chain fatty acid, capric acid, on locomotor activity and anxiety-like and depression-related behaviors in adult male C57BL/6J mice.Neuropsychopharmacology reports · 2022Article
- Neurogenesis and Neuroplasticity in Major Depression: Its Therapeutic Implication.Advances in experimental medicine and biology · 2021Article
- Antidepressant and pro-motivational effects of repeated lamotrigine treatment in a rat model of depressive symptoms.Heliyon · 2018Article
- Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia.The international journal of neuropsychopharmacology · 2016Article
- Predictive Validity of Some Common Animal Models of Bipolar Disorder Using Lithium and Lamotrigine Therapy: An Attempt towards a Battery-Based Approach for the Evaluation of Mood Stabilizers.Psychiatry investigation · 2016Article
- Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice.Scientific reports · 2015Article
- Novel glutamatergic drugs for the treatment of mood disorders.Neuropsychiatric disease and treatment · 2013Article
- Case files of the University of California San Francisco Medical Toxicology Fellowship: lamotrigine toxicity.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2012Article
- Antidepressant response to chronic citalopram treatment in eight inbred mouse strains.Psychopharmacology · 2011Article
- Translational research in bipolar disorder: emerging insights from genetically based models.Molecular psychiatry · 2010Review
- The effectiveness of anticonvulsants in psychiatric disorders.Dialogues in clinical neuroscience · 2008Review
- The role of lamotrigine in the management of bipolar disorder.Neuropsychiatric disease and treatment · 2007Article
- Protective effects of lamotrigine, aripiprazole and escitalopram on depression-induced oxidative stress in rat brain.Neurochemical research · 2007Article
- Factors producing a menopausal depressive-like state in mice following ovariectomy.Psychopharmacology · 2006Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe antiepileptic drug lamotrigine is effective in the treatment of focal epilepsies. It is thought to act by inhibition of glutamate release through blockade of voltage-sensitive sodium channels and stabilization of the neuronal membrane. Lamotrigine is also effective in the treatment of mood disorders such as bipolar disorder. However, its exact mechanism of action in these conditions remains unclear. The aim of the present study was to evaluate the antidepressant-like effect of lamotrigine in a mouse model of depression, namely the forced swimming test (FST). Association studies using specific and nonspecific ligands acting on serotonin (5-hydroxytryptamine; 5-HT1) receptor subtypes were undertaken to evaluate the potential role of these receptors in the anti-immobility effect of lamotrigine.
methodsThe mouse FST was performed after single administration of lamotrigine. Subactive doses of lamotrigine were administered in association with subactive doses of the following 5-HT1 receptor agonists or antagonists: 8-hydroxy-2-(di-n-propilamino)-tetralin (8-OH-DPAT, a standard 5-HT(1A) receptor selective agonist), pindolol (a presynaptic and postsynaptic 5-HT(1A/1B) receptor antagonist), NAN-190 (a 5-HT(1A) receptor antagonist), RU 24969 (a 5-HT(1A/1B) receptor agonist) and anpirtoline (5-HT(1B) agonist).
resultsLamotrigine impaired spontaneous locomotor activity at doses of 4 mg/kg or greater, and activity decreased by more than 50% at the 16 mg/kg dose. When administered alone, lamotrigine (8 and 16 mg/kg) decreased immobility time in the FST. Only 8-OH-DPAT (1 mg/kg), pindolol (32 mg/kg) and RU 24969 (0.5 mg/kg) enhanced the antidepressant-like effect of lamotrigine in the FST.
conclusionsThese results suggest that postsynaptic 5-HT(1A) receptors might be involved in the activity of lamotrigine. Furthermore, they demonstrate that lamotrigine more closely resembles valproate and carbamazepine than lithium, with the advantage of an anti-immobility effect in the mouse FST when administered on its own.
Indexed as
Identifiers
16049571PMC1160563W1589481864What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.