ArticleThe American journal of pathology2005
Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver.
Article in The American journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Cell Fusion in Reprogramming and Regeneration.Advances in experimental medicine and biology · 2026Review
- Therapeutic Cell Repopulation of the Liver: From Fetal Rat Cells to Synthetic Human Tissues.Cells · 2023Review
- Primary Hepatocyte Isolation and Cultures: Technical Aspects, Challenges and Advancements.Bioengineering (Basel, Switzerland) · 2023Review
- The hematopoietic system in the context of regenerative medicine.Methods (San Diego, Calif.) · 2016Review
- Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure.International journal of hepatology · 2016Article
- Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Archives of toxicology · 2013Review
- Fetal liver cell transplantation as a potential alternative to whole liver transplantation?Journal of gastroenterology · 2011Review
- Early stage transplantation of bone marrow cells markedly ameliorates copper metabolism and restores liver function in a mouse model of Wilson disease.BMC gastroenterology · 2011Article
- Alveolar epithelial cell therapy with human cord blood-derived hematopoietic progenitor cells.The American journal of pathology · 2011Article
- Bone marrow stem cells and liver regeneration.Experimental hematology · 2010Review
- Reversal of Hepatic Fibrosis by Human CD34(+) Stem/Progenitor Cell Transplantation in Rats.International journal of stem cells · 2010Article
- Hepatic progenitors for liver disease: current position.Stem cells and cloning : advances and applications · 2010Review
- Contribution of human hematopoietic stem cells to liver repair.Seminars in immunopathology · 2009Review
- Phenotypic changes of human cells in human-rat liver during partial hepatectomy-induced regeneration.World journal of gastroenterology · 2009Article
- Human progenitor cells with high aldehyde dehydrogenase activity efficiently engraft into damaged liver in a novel model.Hepatology (Baltimore, Md.) · 2009Article
- Derivation of lung epithelium from human cord blood-derived mesenchymal stem cells.American journal of respiratory and critical care medicine · 2008Article
- Persistence of a chimerical phenotype after hepatocyte differentiation of human bone marrow mesenchymal stem cells.Cell proliferation · 2008Article
- Stem cells in liver regeneration and therapy.Cell and tissue research · 2008Review
- Review
- The role of stem cells in physiology, pathophysiology, and therapy of the liver.Stem cell reviews · 2006Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differentiation of adult bone marrow (BM) cells into nonhematopoietic cells is a rare phenomenon. Several reports, however, suggest that human umbilical cord blood (hUCB)-derived cells give rise to hepatocytes after transplantation into nonobese diabetic-severe combined immunodeficient (NOD-SCID) mice. Therefore, we analyzed the hepatic differentiation potential of hUCB cells and compared the frequency of newly formed hepatocyte-like cells in the livers of recipient NOD-SCID mice after transplantation of hUCB versus murine BM cells. Mononuclear cell preparations of hUCB cells or murine BM from enhanced green fluorescent protein transgenic or wild-type mice were transplanted into sublethally irradiated NOD-SCID mice. Liver regeneration was induced by carbon tetrachloride injury with and without subsequent hepatocyte growth factor treatment. By immunohistochemistry and reverse transcriptase-polymerase chain reaction, we detected clusters of hepatocyte-like cells in the livers of hUCB-transplanted mice. These cells expressed human albumin and Hep Par 1 but mouse CK18, suggesting the formation of chimeric hepatocyte-like cells. Native fluorescence microscopy and double immunofluorescence failed to detect single hepatocytes derived from transplanted enhanced green fluorescent protein-transgenic mouse BM. Fluorescent in situ hybridization rarely revealed donor-derived hepatocyte-like cells after cross-gender mouse BM transplantation. Thus, hUCB cells have differentiation capabilities different from murine BM cells after transplantation into NOD-SCID mice, demonstrating the importance of further testing before hUCB cells can be used therapeutically.
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