ReviewJournal of clinical pathology2005
Microsatellite instability and gastric non-invasive neoplasia in a high risk population in Cesena, Italy.
Review in Journal of clinical pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Review
- Molecular subtyping of gastroesophageal dysplasia heterogeneity according to TCGA/ACRG classes.Virchows Archiv : an international journal of pathology · 2022Article
- Role of magnifying endoscopy with narrow-band imaging in the diagnosis of noninvasive gastric neoplasia.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Microsatellite Instability and Altered Expressions of MLH1 and MSH2 in Gastric CancerAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Endoscopic and clinicopathologic characteristics of early gastric cancer with high microsatellite instability.World journal of gastroenterology · 2012Article
- Implication of microsatellite instability in human gastric cancers.The Indian journal of medical research · 2012Review
- Lack of association between microsatellite instability and benign adrenal tumors.World journal of surgery · 2006Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsIn the natural history of gastric cancer, non-invasive neoplasia (NiN) precedes invasive carcinoma. A histological classification of gastric NiN has recently been proposed by a World Health Organisation international panel of experts. Genetic instability is known to be among the molecular pathways involved in gastric oncogenesis. In this retrospective cross sectional study, microsatellite instability (MSI) was analysed in a consecutive series of NiN and NiN related histological alterations from a northern Italian region at high risk for gastric cancer. PATIENTS/
methodsFifty five consecutive cases (indefinite for NiN, 29 cases; low grade NiN, 17 cases; high grade NiN, nine cases) were analysed by radioactive polymerase chain reaction and electrophoresis for microsatellite alterations at six loci (BAT25, BAT26, D2S123, D5S346, D17S250, and D3S1317). MSI was defined according to the Bethesda criteria distinguishing: (1) no instability in the analysed loci; (2) low frequency MSI (MSI-L); and (3) high frequency MSI (MSI-H). Immunohistochemical expression of MLH1 and MSH2 proteins was also analysed in all cases.
resultsOverall, MSI was found in 11 of 55 cases (indefinite for NiN, five of 29 (MSI-L, four; MSI-H, one); low grade NiN, three of 17 (MSI-L, one; MSI-H, two); high grade NiN, three of nine (MSI-L, one; MSI-H, two).
conclusionsIn an Italian high risk area for gastric cancer, MSI is part of the spectrum of genetic alterations in gastric non-invasive neoplasia. In European populations at high risk of gastric cancer, DNA repair system alterations are thought to be among the early molecular events in gastric carcinogenesis.
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