ArticleProceedings of the National Academy of Sciences of the United States of America2005
Emergent patterns of growth controlled by multicellular form and mechanics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 349 papers.
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Who cites it
349 citing papers in PubMed.
- Flexible high-resolution ECM micropatterning.Nature protocols · 2026Review
- Mechanics of compression-driven morphogenesis.Development (Cambridge, England) · 2026Review
- Mechanotransductive Osteogenesis Through Microarchitectural Stabilization in an Injectable Hydrogel-Mineral System.Journal of functional biomaterials · 2026Article
- Synchronization enhanced force microscopy for clinical tumor tissue mechanical characterization.Microsystems & nanoengineering · 2026Article
- Cell type-specific response to curvature controls tissue growth dynamics in biomaterial pores.Bioactive materials · 2026Article
- Engineering anisotropic tissues: from structured scaffolds to magnetic actuation.Materials today. Bio · 2026Review
- Cell differentiation can underpin the reproducibility of morphogenesis.PLoS computational biology · 2026Article
- Cardiac-Derived ECM Microspheres for Enhanced hiPSC-CMs Maturation.Advanced functional materials · 2026Article
- In situ mechanostimulation of biohybrid millirobots for enhanced cell functionality and delivery.Science advances · 2026Article
- Geometric mechanogenomics: engineering boundary conditions for deterministic cell fate control.Frontiers in cell and developmental biology · 2026Review
- Magnetic Bioprinting and Actuation of Stretchable Muscle Tissue.Advanced healthcare materials · 2026Article
- Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling.Nature cell biology · 2025Article
- An ingenious design from nature to accelerate the repair of long-bone critical defects: the longitudinal tubular transverse interconnection structure of deer antlers.Materials today. Bio · 2025Article
- Geometrical constraints dictate assembly and phenotype of human iPSC-derived motoneuronal spheroids.Stem cell research & therapy · 2025Article
- Bioprinted platform for parallelized screening of engineered microtissues in vivo.Cell stem cell · 2025Article
- Micropillars in Cell Mechanobiology: Design, Fabrication, Characterization, and Biosensing Applications.Small science · 2025Review
- Physical Forces in Regeneration of Cells and Tissues.Cold Spring Harbor perspectives in biology · 2025Review
- Same same but different? How blood and lymphatic vessels induce cell contact inhibition.Biochemical Society transactions · 2025Review
- Mechanical Cell Interactions on Curved Interfaces.Bulletin of mathematical biology · 2025Article
- Biological boundary conditions regulate the internalization ofFrontiers in cellular and infection microbiology · 2025Article
289 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spatial patterns of cellular growth generate mechanical stresses that help to push, fold, expand, and deform tissues into their specific forms. Genetic factors are thought to specify patterns of growth and other behaviors to drive morphogenesis. Here, we show that tissue form itself can feed back to regulate patterns of proliferation. Using micro-fabrication to control the organization of sheets of cells, we demonstrated the emergence of stable patterns of proliferative foci. Regions of concentrated growth corresponded to regions of high tractional stress generated within the sheet, as predicted by a finite-element model of multicellular mechanics and measured directly by using a micromechanical force sensor array. Inhibiting actomyosin-based tension or cadherin-mediated connections between cells disrupted the spatial pattern of proliferation. These findings demonstrate the existence of patterns of mechanical forces that originate from the contraction of cells, emerge from their multicellular organization, and result in patterns of growth. Thus, tissue form is not only a consequence but also an active regulator of tissue growth.
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