ArticleAntimicrobial agents and chemotherapy2005
Correspondence of in vitro and in vivo fluconazole dose-response curves for Cryptococcus neoformans.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis.Antimicrobial agents and chemotherapy · 2018Article
- Enhanced Killing and Antibiofilm Activity of Encapsulated Cinnamaldehyde againstFrontiers in microbiology · 2017Article
- Pharmacokinetics and pharmacodynamics of fluconazole for cryptococcal meningoencephalitis: implications for antifungal therapy and in vitro susceptibility breakpoints.Antimicrobial agents and chemotherapy · 2013Article
- Cryptococcus neoformans: the model organism for yeast antifungal drug susceptibility testing.Mycopathologia · 2012Article
- Correlation of the in vitro antifungal drug susceptibility with the in vivo activity of fluconazole in a murine model of cerebral infection caused by Cryptococcus gattii.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Article
- In vitro susceptibility of the yeast pathogen cryptococcus to fluconazole and other azoles varies with molecular genotype.Journal of clinical microbiology · 2010Article
- In vitro-clinical correlations for amphotericin B susceptibility in AIDS-associated cryptococcal meningitis.Antimicrobial agents and chemotherapy · 2007Article
- Results obtained with various antifungal susceptibility testing methods do not predict early clinical outcome in patients with cryptococcosis.Antimicrobial agents and chemotherapy · 2006Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
We conducted in vitro experiments to evaluate the susceptibility of a clinical isolate of Cryptococcus neoformans to a wide range of concentrations of fluconazole. In vitro susceptibility was tested using broth macrodilution methods modified to provide a numeric count of viable organisms. The association between the quantitative in vitro response and fluconazole drug concentrations was estimated using local nonparametric regression. Regression analysis was used to assess the correspondence between the in vitro fluconazole concentration-response curve and the murine dose-response curve observed in our previously reported murine model. The regression model was then used to predict the murine response. There was a strong correspondence between in vitro measures of response to fluconazole alone and the previously reported biologic effects seen in the mouse. In vitro antifungal drug susceptibility testing can reliably predict the murine response to fluconazole.
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Registered trials
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