ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2005
Theoretical models of selection and mutation on quantitative traits.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 1 of them a synthesis that pooled it.
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Who cites it
133 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The contribution of additive genetic variation to personality variation: heritability of personality.Proceedings. Biological sciences · 2015Pooled it
- Maintenance of quantitative genetic variation in regions of restricted recombination via associative overdominance.bioRxiv : the preprint server for biology · 2026Article
- Genetic architectures of brain-related traits are shaped by strong selective constraints.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Strong amplification of quantitative genetic variation under a balance between mutation and fluctuating stabilizing selection.Genetics · 2026Article
- A century of theories of balancing selection.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Genetic architectures of brain-related traits are shaped by strong selective constraints.bioRxiv : the preprint server for biology · 2026Article
- The effect of long-range linkage disequilibrium on allele-frequency dynamics under stabilizing selection.PLoS genetics · 2026Article
- Genetic architecture of seed protein composition in grain amaranth (Frontiers in nutrition · 2026Article
- Article
- Within-host microbial selection and multiple microbial generations buffer the loss of host fitness under environmental change.FEMS microbiology ecology · 2025Article
- A Balanced Inversion Polymorphism Exhibits a Dominance Reversal at the Gene Expression Level that Depends on Developmental Context.Molecular biology and evolution · 2025Article
- Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples.American journal of human genetics · 2025Article
- When should adaptation arise from a polygenic response versus few large effect changes?bioRxiv : the preprint server for biology · 2025Article
- Article
- Understanding developmental system drift.Development (Cambridge, England) · 2024Review
- The logic of monsters: development and morphological diversity in stem-cell-based embryo models.Interface focus · 2024Review
- Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples.bioRxiv : the preprint server for biology · 2024Article
- Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis.Arthritis research & therapy · 2024Article
- Fitting and evaluating univariate and multivariate models of within-lineage evolution.Paleobiology · 2023Article
- Reduced within-population quantitative genetic variation is associated with climate harshness in maritime pine.Heredity · 2023Article
73 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
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Abstract
Empirical studies of quantitative genetic variation have revealed robust patterns that are observed both across traits and across species. However, these patterns have no compelling explanation, and some of the observations even appear to be mutually incompatible. We review and extend a major class of theoretical models, 'mutation-selection models', that have been proposed to explain quantitative genetic variation. We also briefly review an alternative class of 'balancing selection models'. We consider to what extent the models are compatible with the general observations, and argue that a key issue is understanding and modelling pleiotropy. We discuss some of the thorny issues that arise when formulating models that describe many traits simultaneously.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.