ArticlePLoS biology2005
Aging and gene expression in the primate brain.
Article in PLoS biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
92 citing papers in PubMed, 177 citations in OpenAlex.
- Brain Spatial Genomics Atlases.Genes · 2026Review
- Patterns of transcriptomic aging in the hippocampus of rhesus macaques highlight midlife transitions.GeroScience · 2026Article
- Privacy-preserving federated unsupervised domain adaptation with application to age prediction from DNA methylation data.Bioinformatics (Oxford, England) · 2025Article
- Review
- Spatially resolved transcriptome of the aging mouse brain.Aging cell · 2024Article
- Gene expression changes in cerebellum induced by dietary restriction.Frontiers in molecular neuroscience · 2023Article
- Neurobiological Mechanisms of Cognitive Decline Correlated with Brain Aging.Advances in experimental medicine and biology · 2023Article
- Imaging Transcriptomics of Brain Disorders.Biological psychiatry global open science · 2022Review
- Inferring mammalian tissue-specific regulatory conservation by predicting tissue-specific differences in open chromatin.BMC genomics · 2022Article
- Statistical testing in transcriptomic-neuroimaging studies: A how-to and evaluation of methods assessing spatial and gene specificity.Human brain mapping · 2022Article
- Normal Aging Induces Changes in the Brain and Neurodegeneration Progress: Review of the Structural, Biochemical, Metabolic, Cellular, and Molecular Changes.Frontiers in aging neuroscience · 2022Review
- Neutrophil dynamics and inflammaging in acute ischemic stroke: A transcriptomic review.Frontiers in aging neuroscience · 2022Review
- Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in Mice.Frontiers in molecular biosciences · 2022Article
- Brain organoids: A promising model to assess oxidative stress-induced central nervous system damage.Developmental neurobiology · 2021Review
- Increased Brain Age Gap Estimate (BrainAGE) in Young Adults After Premature Birth.Frontiers in aging neuroscience · 2021Article
- Resistance, vulnerability and resilience: A review of the cognitive cerebellum in aging and neurodegenerative diseases.Neurobiology of learning and memory · 2020Review
- Improved Human Age Prediction by Using Gene Expression Profiles From Multiple Tissues.Frontiers in genetics · 2020Article
- 547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates.Genome biology · 2019Article
- Computed Tomography Assessment of Brain Atrophy in Centenarians.International journal of environmental research and public health · 2019Article
- Regional mitochondrial DNA and cell-type changes in post-mortem brains of non-diabetic Alzheimer's disease are not present in diabetic Alzheimer's disease.Scientific reports · 2019Observational
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well established that gene expression levels in many organisms change during the aging process, and the advent of DNA microarrays has allowed genome-wide patterns of transcriptional changes associated with aging to be studied in both model organisms and various human tissues. Understanding the effects of aging on gene expression in the human brain is of particular interest, because of its relation to both normal and pathological neurodegeneration. Here we show that human cerebral cortex, human cerebellum, and chimpanzee cortex each undergo different patterns of age-related gene expression alterations. In humans, many more genes undergo consistent expression changes in the cortex than in the cerebellum; in chimpanzees, many genes change expression with age in cortex, but the pattern of changes in expression bears almost no resemblance to that of human cortex. These results demonstrate the diversity of aging patterns present within the human brain, as well as how rapidly genome-wide patterns of aging can evolve between species; they may also have implications for the oxidative free radical theory of aging, and help to improve our understanding of human neurodegenerative diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.