Trial reportDigestive diseases and sciences2005
Does eradication of Helicobacter pylori infection help normalize serum lipid and CRP levels?
Trial report in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- A Comprehensive Survey of the Relationship betweenArchives of Iranian medicine · 2022Pooled it
- Trial
- Helicobacter pylori eradication lowers serum asymmetric dimethylarginine levels.Mediators of inflammation · 2010Trial
- Outcomes ofGastroenterology and hepatology from bed to bench · 2026Review
- Effect ofGut and liver · 2025Article
- Helicobacter pylori infection increases the risk of dyslipidemia in Chinese diabetic Population: a retrospective cross-sectional study.BMC infectious diseases · 2024Article
- The association between Helicobacter pylori infection and the risk for gout in hyperuricemia patients in China - A cross-sectional study.Gut pathogens · 2024Article
- Effect of Helicobacter Pylori Infection on Glucose Metabolism, Lipid Metabolism and Inflammatory Cytokines in Nonalcoholic Fatty Liver Disease Patients.Journal of multidisciplinary healthcare · 2024Article
- Traditional and nontraditional lipid parameters inBiomarkers in medicine · 2024Article
- The Interplay betweenInternational journal of molecular sciences · 2023Review
- Article
- Can neutrophil to lymphocyte ratio be a non-invasive indicator of the presence of duodenal ulcer relatedPractical laboratory medicine · 2023Article
- The effect ofArchives of medical science : AMS · 2022Review
- The Effects ofMiddle East journal of digestive diseases · 2022Article
- Increased Glycated Hemoglobin but Decreased Cholesterol after a Loss ofJournal of personalized medicine · 2021Article
- The Effect ofJournal of clinical medicine · 2021Review
- Relationship BetweenInternational journal of general medicine · 2021Review
- Observational
- Effects ofJournal of clinical biochemistry and nutrition · 2018Article
- The Prevalence of Helicobacter pylori in Estonian Bariatric Surgery Patients.International journal of molecular sciences · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is still unclear whether Helicobacter pylori infection is associated with risk factors for coronary artery disease. The aim of this study was to determine whether eradication of H. pylori infection affects serum lipid levels and C-reactive protein (CRP) levels. Seventy-eight patients who had H. pylori antigen positivity in their stools were enrolled. Clarithromycin, 1 g/day, amoxicillin, 2 g/day, and omeprazole, 40 mg/day, were given for 14 days. Serum total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), and CRP were measured at baseline and 8 weeks after therapy. According to H. pylori stool antigen study after 8 weeks, individuals in whom H. pylori was eradicated were recruited as group A and those in whom H. pylori was not eradicated formed group B. Group A comprised 57 patients, and group B 21 patients. Patients in group A comprised 32 women and 25 men and their ages ranged from 35 to 59 years. Patients in group B included 13 women and 8 men, aged 32-61 years. No significant difference in LDL, TC, or TG serum levels were found between group A and group B. Although CRP and HDL serum levels were found to be the same before and after treatment in group B, CRP levels were found to decrease and HDL levels to increase significantly in group A (P < 0.05). We conclude that H. pylori infection may affect lipid metabolism in a way that could increase the risk of atherosclerosis. Thus H. pylori infection is an independent risk factor for coronary artery disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.