ArticleMolecular genetics and genomics : MGG2005
Structural and functional analysis of 5S rRNA in Saccharomyces cerevisiae.
Article in Molecular genetics and genomics : MGG, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Spatial regulation of ribosomal protein gene expression revealed by spatial transcriptomic analysis in the water fernFrontiers in plant science · 2025Article
- SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs.Experimental & molecular medicine · 2023Article
- Relative specificity as an important consideration in the big data era.Frontiers in genetics · 2022Article
- Expansion segments in bacterial and archaeal 5S ribosomal RNAs.RNA (New York, N.Y.) · 2021Article
- Ribosome engineering reveals the importance of 5S rRNA autonomy for ribosome assembly.Nature communications · 2020Article
- Formation of mammalian preribosomes proceeds from intermediate to composed state during ribosome maturation.The Journal of biological chemistry · 2019Article
- The Discovery of Ribosome Heterogeneity and Its Implications for Gene Regulation and Organismal Life.Molecular cell · 2018Review
- Subtractional Heterogeneity: A Crucial Step toward Defining Specialized Ribosomes.Molecular cell · 2017Article
- Pathways to Specialized Ribosomes: The Brussels Lecture.Journal of molecular biology · 2016Review
- 5SRNAdb: an information resource for 5S ribosomal RNAs.Nucleic acids research · 2016Article
- V-erbA generates ribosomes devoid of RPL11 and regulates translational activity in avian erythroid progenitors.Oncogene · 2014Article
- Eukaryotic rpL10 drives ribosomal rotation.Nucleic acids research · 2014Article
- Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18.Genes & development · 2011Article
- The central core region of yeast ribosomal protein L11 is important for subunit joining and translational fidelity.Molecular genetics and genomics : MGG · 2011Article
- An extensive network of information flow through the B1b/c intersubunit bridge of the yeast ribosome.PloS one · 2011Article
- A molecular clamp ensures allosteric coordination of peptidyltransfer and ligand binding to the ribosomal A-site.Nucleic acids research · 2010Article
- Molecular dynamics simulations suggest that RNA three-way junctions can act as flexible RNA structural elements in the ribosome.Nucleic acids research · 2010Article
- Overexpression of a natural chloroplast-encoded antisense RNA in tobacco destabilizes 5S rRNA and retards plant growth.BMC plant biology · 2010Article
- Dynamics of the base of ribosomal A-site finger revealed by molecular dynamics simulations and Cryo-EM.Nucleic acids research · 2010Article
- Correlation of RNA secondary structure statistics with thermodynamic stability and applications to folding.Journal of molecular biology · 2009Article
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Authors and funding
6 authors.
Funding
Abstract
5S rRNA extends from the central protuberance of the large ribosomal subunit, through the A-site finger, and down to the GTPase-associated center. Here, we present a structure-function analysis of seven 5S rRNA alleles which are sufficient for viability in the yeast Saccharomyces cerevisiae when expressed in the absence of wild-type 5S rRNAs, and extend this analysis using a large bank of mutant alleles that show semi-dominant phenotypes in the presence of wild-type 5S rRNA. This analysis supports the hypothesis that 5S rRNA serves to link together several different functional centers of the ribosome. Data are also presented which suggest that in eukaryotic genomes selection has favored the maintenance of multiple alleles of 5S rRNA, and that these may provide cells with a mechanism to post-transcriptionally regulate gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.