ArticlePediatric radiology2005
Spontaneous regression of residual low-grade cerebellar pilocytic astrocytomas in children.
Article in Pediatric radiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Reconstructing the molecular life history of gliomas.Acta neuropathologica · 2018Pooled it
- Long-term outcome of 4,040 children diagnosed with pediatric low-grade gliomas: an analysis of the Surveillance Epidemiology and End Results (SEER) database.Pediatric blood & cancer · 2014Trial
- Dynamic Tumor Volume Changes after Debulking Surgery of Optic Hypothalamus Pilocytic Astrocytoma.Neurologia medico-chirurgica · 2026Article
- Diffuse Low-Grade Glioma With Spontaneous Radiological Regression: A Case to Be Followed.Cureus · 2025Article
- Prognostic factors of thalamic and thalamopeduncular low-grade gliomas in children: A systematic review and recommendations for surgical management.Brain & spine · 2025Review
- Towards a Risk-Based Follow-Up Surveillance Imaging Schedule for Children and Adolescents with Low-Grade Glioma.Current oncology (Toronto, Ont.) · 2024Review
- Review
- Survival and functional outcomes in paediatric thalamic and thalamopeduncular low grade gliomas.Acta neurochirurgica · 2022Article
- Pediatric and Adult Low-Grade Gliomas: Where Do the Differences Lie?Children (Basel, Switzerland) · 2021Review
- Twenty-three years follow-up after low-dose Gamma Knife surgery of a brainstem juvenile pilocytic astrocytoma: a case report and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Review
- Mortality in children with low-grade glioma or glioneuronal tumors: A single-institution study.Pediatric blood & cancer · 2018Article
- Article
- Vanishing pineal mass in a young patient without therapy: Case report and review of the literature.The neuroradiology journal · 2016Review
- Postoperative surveillance of pediatric cerebellar pilocytic astrocytoma.Journal of neuro-oncology · 2016Article
- Model-Based Evaluation of Spontaneous Tumor Regression in Pilocytic Astrocytoma.PLoS computational biology · 2015Article
- Pediatric low-grade gliomas: how modern biology reshapes the clinical field.Biochimica et biophysica acta · 2014Review
- Arrested growth and spontaneous tumor regression of partially resected low-grade cerebellar astrocytomas in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Article
- Identification of new HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from neuritin.Journal of neuro-oncology · 2013Article
- Neurological morbidity of surgical resection of pediatric cerebellar astrocytomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Article
- Pathological and molecular advances in pediatric low-grade astrocytoma.Annual review of pathology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebellar low-grade astrocytomas (CLGAs) of childhood are benign tumours and are usually curable by surgical resection alone or combined with adjuvant radiotherapy.
objectiveTo undertake a retrospective study of our children with CLGA to determine the optimum schedule for surveillance imaging following initial surgery. In this report we describe the phenomenon of spontaneous regression of residual tumour and discuss its prognostic significance regarding future imaging. MATERIALS AND
methodsA retrospective review was conducted of children treated for histologically proven CLGA at Great Ormond Street Hospital from 1988 to 1998.
resultsOf 83 children with CLGA identified, 13 (15.7%) had incomplete resections. Two children with large residual tumours associated with persistent symptoms underwent additional treatment. Eleven children were followed by surveillance imaging alone for a mean of 6.83 years (range 2-13.25 years). Spontaneous tumour regression was seen in 5 (45.5%) of the 11 children. There were no differences in age, gender, symptomatology, histological grade or Ki-67 fractions between those with spontaneous tumour regression and those with progression. There was a non-significant trend that larger volume residual tumours progressed.
conclusionsResidual tumour followed by surveillance imaging may either regress or progress. For children with residual disease we recommend surveillance imaging every 6 months for the first 2 years, every year for years 3, 4 and 5, then every second year if residual tumour is still present 5 years after initial surgery. This would detect not only progressive or recurrent disease, but also spontaneous regression which can occur later than disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.