ArticleEuropean journal of clinical pharmacology2005
Drug-drug interactions among recently hospitalised patients--frequent but mostly clinically insignificant.
Article in European journal of clinical pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00738816 (The Effect of Systematic Medication Review in Elderly Patients Admitted to an Orthopedic Department.), which is not on this map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Systematic Medication Review in Elderly Patients Admitted to an Orthopedic Department.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Adverse effects of plant food supplements and botanical preparations: a systematic review with critical evaluation of causality.British journal of clinical pharmacology · 2015Pooled it
- Drug-drug interactions in inpatient and outpatient settings in Iran: a systematic review of the literature.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2014Pooled it
- Potential drug-drug interactions among geriatric oncology patients: a retrospective study in Saudi Arabia.BMC geriatrics · 2025Article
- Drug interactions in hospital prescriptions in Denmark: Prevalence and associations with adverse outcomes.Pharmacoepidemiology and drug safety · 2022Article
- The Prevalence of Potential Drug-Drug Interactions in CKD-A Retrospective Observational Study of Cerrahpasa Nephrology Unit.Medicina (Kaunas, Lithuania) · 2022Observational
- Drug-Drug-Gene Interactions in Cardiovascular Medicine.Pharmacogenomics and personalized medicine · 2022Review
- Review
- Prevalence and nature of potential drug-drug interactions among hospitalized HIV patients presenting with suspected meningitis in Uganda.BMC infectious diseases · 2020Article
- Effects of Phenothiazines on Aldehyde Oxidase Activity Towards Aldehydes and N-Heterocycles: an In Vitro and In Silico Study.European journal of drug metabolism and pharmacokinetics · 2019Article
- Comparative analysis of three drug-drug interaction screening systems against probable clinically relevant drug-drug interactions: a prospective cohort study.European journal of clinical pharmacology · 2017Article
- Review
- Potential drug-drug interactions among hospitalized patients in a developing country.Caspian journal of internal medicine · 2017Article
- Understanding and preventing drug-drug and drug-gene interactions.Expert review of clinical pharmacology · 2014Review
- Actual drug-drug interactions in elderly patients discharged from internal medicine clinic: a prospective observational study.European journal of clinical pharmacology · 2013Observational
- Characterisation of non-warfarin-associated bleeding events reported to the Norwegian spontaneous reporting system.European journal of clinical pharmacology · 2013Article
- Agreement among four drug information sources for the occurrence of warfarin drug interactions in Brazilian heart disease patients with a high prevalence of Trypanosoma cruzi infection.European journal of clinical pharmacology · 2013Article
- Prevalence of potential drug-drug interactions in cancer patients treated with oral anticancer drugs.British journal of cancer · 2013Article
- Potential of Drug Interactions among Hospitalized Cancer Patients in a Developing Country.Iranian journal of pharmaceutical research : IJPR · 2013Article
- Prevalence of drug interactions in hospital healthcare.International journal of clinical pharmacy · 2012Review
- Inappropriate prescribing for older people admitted to an intermediate-care nursing home unit and hospital wards.Scandinavian journal of primary health care · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePatients use and store considerable amounts of drugs. The aim of the present study was to identify potential drug-drug interactions between drugs used by patients recently discharged from the hospital and, subsequently, to estimate the clinical implications of these interactions.
methodsPatients were visited within 1 week following their discharge from hospital and interviewed about their drug use. Stored products were inspected. We used a bibliography (Hansten and Horn; Wolters Kluwer Health, St. Louis, Mo., 2004) to identify and classify potential drug-drug interactions.
resultsIn total, 83 surgical and 117 medical patients (n = 200) were included in the survey, of which 139 (70%) were women. The median age was 75 years (range: 24-100 years). Patients stored 2119 medications at home (median: nine per patient; range: 2-44) and used 1622 medications daily or on demand (median: eight per patient; range: 1-24). With respect to those drugs used daily or on demand, 476 potential interactions were identified (126 patients); none were class 1 (always avoid drug combination) and 25 were class 2 (usually avoid combination; 24 patients). Eleven of the potential class 2 interactions involved over-the-counter products (aspirin and ginkgo biloba). Of the 52 drugs involved in potential class 2 interactions, 50 had been used for more than 1 month. According to the hospital case notes, none of the potential class 2 interactions had actually caused adverse effects.
conclusionAlthough potential drug-drug interactions are highly prevalent, serious and clinically significant interactions are rare among recently hospitalised patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.