ArticleJournal of biomedicine & biotechnology2005
Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes.
Article in Journal of biomedicine & biotechnology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart.Cardiovascular research · 2017Guideline
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- Exploring the key role of DNA methylation as an epigenetic modulator in oxidative stress related islet cell injury in patients with type 2 diabetes mellitus: a review.Journal of diabetes and metabolic disorders · 2024Review
- The impact of site-specific DNA methylation inHeliyon · 2024Article
- Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management.Frontiers in endocrinology · 2022Review
- The link among microbiota, epigenetics, and disease development.Environmental science and pollution research international · 2021Review
- Article
- Life-style-induced metabolic derangement and epigenetic changes promote diabetes and oxidative stress leading to NASH and atherosclerosis severity.Journal of diabetes and metabolic disorders · 2018Article
- System biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders.Progress in neurobiology · 2018Review
- Elevation ofExperimental and therapeutic medicine · 2017Article
- DNA methylation of candidate genes in peripheral blood from patients with type 2 diabetes or the metabolic syndrome.PloS one · 2017Article
- Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation.Clinical epigenetics · 2017Article
- Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy.World journal of diabetes · 2015Article
- Epigenome: biosensor of cumulative exposure to chemical and nonchemical stressors related to environmental justice.American journal of public health · 2014Article
- DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Observational
- Use of epigenetic drugs in disease: an overview.Genetics & epigenetics · 2014Review
- Differential methylation of TCF7L2 promoter in peripheral blood DNA in newly diagnosed, drug-naïve patients with type 2 diabetes.PloS one · 2014Article
- Race/Ethnicity, Obesity, and Related Cardio-Metabolic Risk Factors: A Life-Course Perspective.Current cardiovascular risk reports · 2013Review
- Epigenetics: the missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes.Epigenetics · 2012Review
- A Realtime and Continuous Assessment of Cortisol in ISF Using Electrochemical Impedance Spectroscopy.Sensors and actuators. A, Physical · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The etiological origin of type 2 diabetes mellitus (T2DM) has long been controversial. The body of literature related to T2DM is vast and varied in focus, making a broad epidemiological perspective difficult, if not impossible. A data-mining approach was used to analyze all electronically available scientific literature, over 12 million Medline records, for "objects" such as genes, diseases, phenotypes, and chemical compounds linked to other objects within the T2DM literature but were not themselves within the T2DM literature. The goal of this analysis was to conduct a comprehensive survey to identify novel factors implicated in the pathology of T2DM by statistically evaluating mutually shared associations. Surprisingly, epigenetic factors were among the highest statistical scores in this analysis, strongly implicating epigenetic changes within the body as causal factors in the pathogenesis of T2DM. Further analysis implicates adipocytes as the potential tissue of origin, and cytokines or cytokine-like genes as the dysregulated factor(s) responsible for the T2DM phenotype. The analysis provides a wealth of literature supporting this hypothesis, which-if true-represents an important paradigm shift for researchers studying the pathogenesis of T2DM.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.