ArticleProtein science : a publication of the Protein Society2005
Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications.
Article in Protein science : a publication of the Protein Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 94 citations in OpenAlex.
- Exploring the Binding Specificity of Siglec-Derived Peptides to Human Primary Amine Oxidase Using an Integrative Approach to Ligand Epitope Mapping.Computational and structural biotechnology journal · 2026Article
- The role of VAP-1 in cardiovascular disease: a review.Frontiers in cardiovascular medicine · 2025Review
- Human Copper-Containing Amine Oxidases in Drug Design and Development.Molecules (Basel, Switzerland) · 2020Review
- Protein-Derived Cofactors Revisited: Empowering Amino Acid Residues with New Functions.Biochemistry · 2018Review
- Mapping the interaction site and effect of the Siglec-9 inflammatory biomarker on human primary amine oxidase.Scientific reports · 2018Article
- Copper amine oxidase 8 regulates arginine-dependent nitric oxide production in Arabidopsis thaliana.Journal of experimental botany · 2017Article
- Probing the Catalytic Mechanism of Copper Amine Oxidase from Arthrobacter globiformis with Halide Ions.The Journal of biological chemistry · 2015Article
- Copper active sites in biology.Chemical reviews · 2014Review
- Human copper-dependent amine oxidases.Archives of biochemistry and biophysics · 2014Review
- Novel pyridazinone inhibitors for vascular adhesion protein-1 (VAP-1): old target-new inhibition mode.Journal of medicinal chemistry · 2013Article
- Structural snapshots from the oxidative half-reaction of a copper amine oxidase: implications for O2 activation.The Journal of biological chemistry · 2013Article
- Structural comparison of the active site channels in rodent and primate vascular adhesion protein-1.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Cellular localization and trafficking of vascular adhesion protein-1 as revealed by an N-terminal GFP fusion protein.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Structural analysis of aliphatic versus aromatic substrate specificity in a copper amine oxidase from Hansenula polymorpha.Biochemistry · 2013Article
- Nuclear imaging of inflammation: homing-associated molecules as targets.EJNMMI research · 2013Article
- Vascular adhesion protein 1 in the eye.Journal of ophthalmology · 2013Article
- Article
- The precursor form of Hansenula polymorpha copper amine oxidase 1 in complex with CuI and CoII.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
- The role of protein crystallography in defining the mechanisms of biogenesis and catalysis in copper amine oxidase.International journal of molecular sciences · 2012Article
- Implication for functions of the ectopic adipocyte copper amine oxidase (AOC3) from purified enzyme and cell-based kinetic studies.PloS one · 2012Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of human vascular adhesion protein-1 (hVAP-1) is induced at sites of inflammation where extravasation of lymphocytes from blood to the peripheral tissue occurs. We have solved the X-ray structure of hVAP-1, a human copper amine oxidase (CAO), which is distinguished from other CAOs in being membrane-bound. The dimer structure reveals some intriguing features that may have fundamental roles in the adhesive and enzymatic functions of hVAP-1, especially regarding the role of hVAP-1 in inflammation, lymphocyte attachment, and signaling. Firstly, Leu469 at the substrate channel may play a key role in controlling the substrate entry; depending on its conformation, it either blocks or gives access to the active site. Secondly, sugar units are clearly observed at two of the six predicted N-glycosylation sites. Moreover, mutagenesis analysis showed that all of the predicted sites were glycosylated in the protein used for crystallization. Thirdly, the existence of a solvent-exposed RGD motif at the entrance to each active site in hVAP-1 suggests that it may have a functional role.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.