ArticleProceedings of the National Academy of Sciences of the United States of America2005
Functional conformational motions in the turnover cycle of cholesterol oxidase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
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- Observation of E-cadherin adherens junction dynamics with metal-induced energy transfer imaging and spectroscopy.Communications biology · 2024Article
- Memory effects of transcription regulator-DNA interactions in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Aqueous ionic liquids redistribute local enzyme stability via long-range perturbation pathways.Computational and structural biotechnology journal · 2021Article
- Shedding light on protein folding, structural and functional dynamics by single molecule studies.Molecules (Basel, Switzerland) · 2014Review
- Probing protein multidimensional conformational fluctuations by single-molecule multiparameter photon stamping spectroscopy.The journal of physical chemistry. B · 2014Article
- Electrochemical tunnelling sensors and their potential applications.Nature communications · 2012Article
- Biochemistry. Enzymes in coherent motion.Science (New York, N.Y.) · 2012Article
- Probing single-molecule enzyme active-site conformational state intermittent coherence.Journal of the American Chemical Society · 2011Article
- Nonparametric Inference of Doubly Stochastic Poisson Process Data via the Kernel Method.The annals of applied statistics · 2010Article
- Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Time-dependent molecular memory in single voltage-gated sodium channel.The Journal of membrane biology · 2007Article
- Nonlinear relaxation dynamics in elastic networks and design principles of molecular machines.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
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Authors and funding
3 authors.
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Abstract
Reexamining experimental data of single-molecule fluorescence correlation spectroscopy for cholesterol oxidase, we find that the existing Michaelis-Menten models with dynamical disorder cannot explain strong correlations between subsequent turnover cycles revealed in the diagonal feature in the joint statistical distribution of adjacent "on" times of this enzyme. We suggest that functional conformational motions representing ordered sequences of transitions between a set of conformational substates are involved, along with equilibrium conformational fluctuations in the turnover cycle of cholesterol oxidase. A two-channel model of single-enzyme dynamics, including a slow functional conformational motion in one of the channels, is proposed that allows us to reproduce such strong correlations.
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