ArticleJournal of controlled release : official journal of the Controlled Release Society2005
The role of cavitation in acoustically activated drug delivery.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed.
- Clinical and Microbiological Effects of Weekly Supragingival Irrigation with Aerosolized 0.5% Hydrogen Peroxide and Formation of Cavitation Bubbles in Gingival Tissues after This Irrigation: A Six-Month Randomized Clinical Trial.Oxidative medicine and cellular longevity · 2020Trial
- Effect of Supragingival Irrigation with Aerosolized 0.5% Hydrogen Peroxide on Clinical Periodontal Parameters, Markers of Systemic Inflammation, and Morphology of Gingival Tissues in Patients with Periodontitis.Medical science monitor : international medical journal of experimental and clinical research · 2016Trial
- Assessment of Cavitation From DEFINITY and DEFINITY RT.Ultrasound in medicine & biology · 2026Article
- Dual-Modality Ultrasound Imaging of SPIONs Distribution via Combined Magnetomotive and Passive Cavitation Imaging.Sensors (Basel, Switzerland) · 2025Article
- Two-step ultrasonic cavitation controlled delivery of brain exogenous nucleic acids for ischemic stroke using acoustic-cationic-polymeric-nanodroplets.Drug delivery and translational research · 2025Article
- Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery.Ultrasonics sonochemistry · 2025Article
- Ultrasound-cavitation-enhanced drug delivery via microbubble clustering induced by acoustic vortex tweezers.Ultrasonics sonochemistry · 2025Article
- Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma.Communications materials · 2025Review
- Acoustic droplet vaporization for on-demand modulation of microporosity in smart hydrogels.Acta biomaterialia · 2023Article
- Design and optimization various formulations of PEGylated niosomal nanoparticles loaded with phytochemical agents: potential anti-cancer effects against human lung cancer cells.Pharmacological reports : PR · 2023Article
- Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes.Pharmaceutics · 2023Review
- Ultrasound-Responsive Nanocarriers for Breast Cancer Chemotherapy.Micromachines · 2022Review
- Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Perspective on ultrasound bioeffects and possible implications for continuous post-dive monitoring safety.Diving and hyperbaric medicine · 2022Review
- Ultrasound-Responsive Systems as Components for Smart Materials.Chemical reviews · 2022Review
- Ultrasound-Targeted Microbubble Destruction: Modulation in the Tumor Microenvironment and Application in Tumor Immunotherapy.Frontiers in immunology · 2022Review
- Collapse pressure measurement of single hollow glass microsphere using single-beam acoustic tweezer.Ultrasonics sonochemistry · 2022Article
- Drug Delivery by Ultrasound-Responsive Nanocarriers for Cancer Treatment.Pharmaceutics · 2021Review
- Effects of Non-thermal Ultrasound on a Fibroblast Monolayer Culture: Influence of Pulse Number and Pulse Repetition Frequency.Sensors (Basel, Switzerland) · 2021Article
- Mechanically Induced Cavitation in Biological Systems.Life (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from these polymeric carriers. In this study, an ultrasonic exposure chamber with fluorescence detection was used to examine the mechanism of doxorubicin release from P105 micelles. Acoustic spectra were collected and analyzed, at the same spatial position as fluorescence data, to probe the role of cavitation in drug release. Our study showed a strong correlation between percent drug release and subharmonic acoustic emissions, and we attribute the drug release to collapse cavitation that perturbs the structure of the micelle and releases drug.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.