ArticleCancer cell international2005
Therapeutic Electromagnetic Field (TEMF) and gamma irradiation on human breast cancer xenograft growth, angiogenesis and metastasis.
Article in Cancer cell international, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Beyond Tumor Treating Fields: Multimodal Antitumor Action and the Clinical Potential of Pulsed Electromagnetic Fields.Current medical science · 2026Review
- Human Responses to Magnetic and Hypomagnetic Fields: Available Evidence and Potential Risks for Deep Space Travel.Life (Basel, Switzerland) · 2025Review
- Anti-tumor effect of innovative tumor treatment device OM-100 through enhancing anti-PD-1 immunotherapy in glioblastoma growth.Scientific reports · 2024Article
- Effects of extremely low frequency electromagnetic fields on the tumor cell inhibition and the possible mechanism.Scientific reports · 2023Article
- Progressive Study on the Non-thermal Effects of Magnetic Field Therapy in Oncology.Frontiers in oncology · 2021Review
- Mechanisms and therapeutic effectiveness of pulsed electromagnetic field therapy in oncology.Cancer medicine · 2016Review
- BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage.PloS one · 2016Article
- Optimization of a therapeutic electromagnetic field (EMF) to retard breast cancer tumor growth and vascularity.Cancer cell international · 2014Article
- Could radiotherapy effectiveness be enhanced by electromagnetic field treatment?International journal of molecular sciences · 2013Review
- Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing mice.Frontiers in oncology · 2013Article
- Low intensity and frequency pulsed electromagnetic fields selectively impair breast cancer cell viability.PloS one · 2013Article
- Inhibition of angiogenesis mediated by extremely low-frequency magnetic fields (ELF-MFs).PloS one · 2013Article
- Effect of electromagnetic field exposure on the reproductive system.Clinical and experimental reproductive medicine · 2012Article
- The anti-tumor effect of A3 adenosine receptors is potentiated by pulsed electromagnetic fields in cultured neural cancer cells.PloS one · 2012Article
- The effects of acute and chronic psychological stress on bladder function in a rodent model.Urology · 2011Article
- Effect of magnetic fields on tumor growth and viability.Comparative medicine · 2011Article
- Sequentially Programmed Magnetic Field Therapy in the Management of Recurrent Anaplastic Astrocytoma: A Case Report and Literature Review.Case reports in oncology · 2010Article
- Anti-proliferative effect of extremely low frequency electromagnetic field on preneoplastic lesions formation in the rat liver.BMC cancer · 2010Article
- 1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice.Breast cancer research : BCR · 2007Article
- Endothelial cell pseudopods and angiogenesis of breast cancer tumors.Cancer cell international · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe effects of a rectified semi-sinewave signal (15 mT amplitude, 120 pulses per second, EMF Therapeutics, Inc.) (TEMF) alone and in combination with gamma irradiation (IR) therapy in nude mice bearing a human MDA MB231 breast cancer xenograft were tested. Green fluorescence protein transfected cancer cells were injected into the mammary fat pad of young female mice. Six weeks later, mice were randomly divided into four treatment groups: untreated controls; 10 minute daily TEMF; 200 cGy of IR every other day (total 800 cGy); IR plus daily TEMF. Some mice in each group were euthanized 24 hours after the end of IR. TEMF treatment continued for 3 additional weeks. Tumor sections were stained for: endothelial cells with CD31 and PAS or hypoxia inducible factor 1alpha (HIF).
resultsMost tumors <35 mm3 were white but tumors >35 mm3 were pink and had a vascularized capsule. The cortex within 100 microns of the capsule had little vascularization. Blood vessels, capillaries, and endothelial pseudopods were found at >100 microns from the capsule (subcortex). Tumors >35 mm3 treated with IR 24 hours previously or with TEMF had decreased blood vessels in the subcortex and more endothelial pseudopods projecting into hypoxic, HIF positive areas than tumors from the control group. Mice that received either IR or TEMF had significantly fewer lung metastatic sites and slower tumor growth than did untreated mice. No harmful side effects were attributed to TEMF.
conclusionTEMF therapy provided a safe means for retarding tumor vascularization, growth and metastasis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.