ArticleInternational journal of experimental pathology2005
Combined small-cell carcinoma of the stomach: p53 and K-ras gene mutational analysis supports a monoclonal origin of three histological components.
Article in International journal of experimental pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Isoforms of the p53 Family and Gastric Cancer: A Ménage à Trois for an Unfinished Affair.Cancers · 2021Review
- Gastric small-cell carcinoma found on esophagogastroduodenoscopy: a case report and literature review.Case reports in oncological medicine · 2013Article
- Unusual case of small cell gastric carcinoma: case report and literature review.Digestive diseases and sciences · 2011Review
- An autopsy case of primary small cell gastric carcinoma and adenocarcinoma.Clinical journal of gastroenterology · 2010Article
- Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2009Article
- Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progression.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2009Article
- Metastatic small cell carcinoma to the thyroid gland: a pathologic and molecular study demonstrating the origin in the urinary bladder.Endocrine pathology · 2008Article
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6 authors at 1 institution in 1 country.
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Abstract
Primary small-cell carcinoma (SmCC) is extremely rare in stomach. We reported an autopsy case of combined gastric SmCC with p53 and K-ras mutational analysis. Histologically, the tumour was composed of well-differentiated adenocarcinoma surrounding the central dominant SmCC component with scattered nests of squamous cell carcinoma. Immunohistochemically, all the neoplastic components revealed strong expression for p53 protein. Based on these findings, we hypothesized that these histologically different components originated from a same progenitor cell that possessed p53 mutation. Using Laser-capture microdissection technique and mutational analysis, we identified the same point mutations of p53 gene (A-->G transversion in codon 239) and K-ras gene (G-->A transversion in codon 13) in all the neoplastic components, but not in the adjacent normal gastric epithelium. Our results strongly support a hypothesis that the combined SmCC of stomach in this case was of monoclonal origin.
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