ArticleMolecular psychiatry2005
Alternative transcripts and evidence of imprinting of GNAL on 18p11.2.
Article in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Development of novel biosensors to study receptor-mediated activation of the G-protein α subunits GThe Journal of biological chemistry · 2017Article
- High-resolution chromosome ideogram representation of recognized genes for bipolar disorder.Gene · 2016Article
- Identification of genomic locus responsible for experimentally induced testicular teratoma 1 (ett1) on mouse Chr 18.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Mutations in GNAL: a novel cause of craniocervical dystonia.JAMA neurology · 2014Article
- Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia.Epigenetics · 2013Article
- Mutations in GNAL cause primary torsion dystonia.Nature genetics · 2013Article
- Article
- Identification of a specific assembly of the g protein golf as a critical and regulated module of dopamine and adenosine-activated cAMP pathways in the striatum.Frontiers in neuroanatomy · 2011Article
- Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2010Article
- Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Schizophrenia and birthplace of paternal and maternal grandfather in the Jerusalem perinatal cohort prospective study.Schizophrenia research · 2009Article
- Uniparentalism in sporadic colorectal cancer is independent of imprint status, and coordinate for chromosomes 14 and 18.Cancer genetics and cytogenetics · 2009Article
- Highly individual methylation patterns of alternative glucocorticoid receptor promoters suggest individualized epigenetic regulatory mechanisms.Nucleic acids research · 2008Article
- Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2008Article
- The myelin-pathogenesis puzzle in schizophrenia: a literature review.Molecular psychiatry · 2008Review
- Monosomy 18p.Orphanet journal of rare diseases · 2008Review
- Epigenetics in mood disorders.Environmental health and preventive medicine · 2008Article
- Investigation of the G protein subunit Galphaolf gene (GNAL) in attention deficit/hyperactivity disorder.Journal of psychiatric research · 2008Article
- Dense SNP association study for bipolar I disorder on chromosome 18p11 suggests two loci with excess paternal transmission.Molecular psychiatry · 2007Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic studies implicating the region of human chromosome 18p11.2 in susceptibility to bipolar disorder and schizophrenia have observed parent-of-origin effects that may be explained by genomic imprinting. We have identified a transcriptional variant of the GNAL gene in this region, employing an alternative first exon that is 5' to the originally identified start site. This alternative GNAL transcript encodes a longer functional variant of the stimulatory G-protein alpha subunit, Golf. The isoforms of Golf display different expression patterns in the CNS and functionally couple to the dopamine D1 receptor when heterologously expressed in Sf9 cells. In addition, there are CpG islands in the vicinity of both first exons that are differentially methylated, a hallmark of genomic imprinting. These results suggest that GNAL, and possibly other genes in the region, is subject to epigenetic regulation and strengthen the case for a susceptibility gene in this region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.