ArticleMolecular psychiatry2005
Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia.
Article in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- PDLIM5 and susceptibility to bipolar disorder: a family-based association study and meta-analysis.Psychiatric genetics · 2008Pooled it
- Insights into neuroscience from the representative birth cohort samples of a multidisciplinary longitudinal study.Acta neuropsychiatrica · 2026Review
- Integrated analysis of molecular atlases unveils modules driving developmental cell subtype specification in the human cortex.Nature neuroscience · 2025Article
- Exploring the PDZ, DUF, and LIM Domains of Pdlim5 in Dendrite Branching.International journal of molecular sciences · 2024Article
- Role of a Pdlim5:PalmD complex in directing dendrite morphology.Frontiers in cellular neuroscience · 2024Article
- The unexpected versatility of ALP/Enigma family proteins.Frontiers in cell and developmental biology · 2022Review
- Ciliary GPCR-based transcriptome as a key regulator of cilia length control.FASEB bioAdvances · 2021Article
- Novel phospho-switch function of delta-catenin in dendrite development.The Journal of cell biology · 2020Article
- Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus.Journal of genetics · 2016Article
- Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia.Translational psychiatry · 2015Article
- Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.Frontiers in psychiatry · 2015Review
- Experimental evidence for the involvement of PDLIM5 in mood disorders in hetero knockout mice.PloS one · 2013Article
- PDLIM5 gene polymorphisms and short term antidepressant response in Chinese major depressive disorders.International journal of clinical and experimental medicine · 2013Article
- Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration.BMC medical genetics · 2012Article
- Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors.Molecular psychiatry · 2012Article
- The Brisbane Systems Genetics Study: genetical genomics meets complex trait genetics.PloS one · 2012Article
- Identification of blood biomarkers for psychosis using convergent functional genomics.Molecular psychiatry · 2011Article
- Analysis of whole genome biomarker expression in blood and brain.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Postsynaptic PDLIM5/Enigma Homolog binds SPAR and causes dendritic spine shrinkage.Molecular and cellular neurosciences · 2010Article
- Positive association between the PDLIM5 gene and bipolar disorder in the Chinese Han population.Journal of psychiatry & neuroscience : JPN · 2009Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously reported that expression level of LIM (ENH, PDLIM5) was significantly and commonly increased in the brains of patients with bipolar disorder, schizophrenia, and major depression. Expression of LIM was decreased in the lymphoblastoid cells derived from patients with bipolar disorders and schizophrenia. LIM protein reportedly plays an important role in linking protein kinase C with calcium channel. These findings suggested the role of LIM in the pathophysiology of bipolar disorder and schizophrenia. To further investigate the role of LIM in these mental disorders, we performed a replication study of gene expression analysis and performed genetic association studies. Upregulation of LIM was confirmed in the independent sample set obtained from Stanley Array Collection. No effect of sample pH or medication was observed. Genetic association study revealed the association of single nucleotide polymorphism (SNP)1 (rs10008257) with bipolar disorder. In an independent sample set, SNP2 (rs2433320) close to SNP1 was associated with bipolar disorder. In total samples, haplotype of these two SNPs was associated with bipolar disorder. No association was observed in case-control analysis and family-based association analysis in schizophrenia. These results suggest that SNPs in the upstream region of LIM may confer the genetic risk for bipolar disorder.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.