ArticleOncogene2005
Absence of mutation in the putative tumor-suppressor gene KLF6 in colorectal cancers.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Krüppel-like Factor 6 Suppresses the Progression of Pancreatic Cancer by Upregulating Activating Transcription Factor 3.Journal of clinical medicine · 2022Article
- MUTYH and KLF6 gene expression fluctuations in tumor tissue and tumor margins tissues of colorectal cancer.Journal of the Egyptian National Cancer Institute · 2022Article
- Meiotic nuclear divisions 1 (MND1) fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma.Cancer communications (London, England) · 2021Article
- Review
- Genetic heterogeneity of primary lesion and metastasis in small intestine neuroendocrine tumors.Scientific reports · 2018Article
- Mutations and Krüppel-like factor 6 (KLF6) expression levels in breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Krüppel-like factor 6 expression changes during trophoblast syncytialization and transactivates ßhCG and PSG placental genes.PloS one · 2011Article
- Mammalian Krüppel-like factors in health and diseases.Physiological reviews · 2010Review
- KLF6 Gene and early melanoma development in a collagen I-rich extracellular environment.Journal of the National Cancer Institute · 2010Article
- Article
- Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis.Current genomics · 2009Article
- Functional role of the KLF6 tumour suppressor gene in gastric cancer.European journal of cancer (Oxford, England : 1990) · 2009Article
- The Pathobiology of Krüppel-like Factors in Colorectal Cancer.Current colorectal cancer reports · 2008Article
- Mutations in the 3'-untranslated region of GATA4 as molecular hotspots for congenital heart disease (CHD).BMC medical genetics · 2007Article
- Somatic mutations in cardiac malformations.Journal of medical genetics · 2006Article
- Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status.The American journal of pathology · 2006Article
- Aberrant expression of krUppel-like factor 6 protein in colorectal cancers.World journal of gastroenterology · 2006Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The KLF6 gene encodes the Krüppel-like factor 6, a transcription factor that has been individualized as a tumor-suppressor gene involved in the regulation of cell proliferation and differentiation. Recently, high frequency (42%) of KLF6 mutations have been reported in colorectal cancers (CRC) as in prostate cancers, astrocytic gliomas and hepatocellular carcinomas. The aims of the study was to confirm the frequency of KLF6 mutations in a larger series of CRC than that previously published by using DNA extracted from frozen tissue samples, which have been proved to generate less mutational artefact than that extracted from formalin-fixed paraffin-embedded tissue samples, in order to compare KLF6 mutation frequency with that of other common genetic alterations and to determine genotype-phenotype correlations. Amplification and direct sequencing of KLF6 exon 2 of 76 CRC and matched normal frozen tissues was performed. Polymorphisms were observed in 14 cases, among which two (T35T and S116S) had not already been reported. No KLF6 somatic mutation was observed. Our data suggest a minor role of KLF6 mutation in colorectal carcinogenesis and underline the fact that the validity of sequence informations obtained from DNA extracted from formalin-fixed tissues may be limited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.