Evidence map›Paper›PMID 16044134›Full record

ArticleBone marrow transplantation2005

Long-term renal function after hemopoietic stem cell transplantation in children.

J E Kist-van Holthe, D Bresters, Y M Ahmed-Ousenkova, C A Goedvolk, F C H Abbink, R Wolterbeek, R G M Bredius, E K J Pauwels, A J van der Heijden

Abstract read
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Chronic kidney disease after hematopoietic cell transplantation: a systematic review.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2008
    Pooled it
  2. Late Effects Following Hematopoietic Stem Cell Transplantation Among Childhood Transplant Survivors with Fanconi AnemiaTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025
    Article
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  14. Hypertension in long-term survivors of pediatric hematopoietic cell transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2010
    Article
  15. Article
  16. Nephrotoxicity as a cause of acute kidney injury in children.Pediatric nephrology (Berlin, Germany) · 2008
    Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

J E Kist-van HoltheDepartment of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands. j.kist@lumc.nl
D Bresters
Y M Ahmed-Ousenkova
C A Goedvolk
F C H Abbink
R Wolterbeek
R G M Bredius
E K J Pauwels
A J van der Heijden
Leiden University Medical Center · NLErasmus MC - Sophia Children’s Hospital · NLLeiden University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glomerular function of all long-term survivors who underwent hemopoietic stem cell transplantation (HSCT) from 1991 to 1998 (study I, n=121) was studied retrospectively. In addition, we prospectively analyzed glomerular and tubular function of all long-term surviving children who received an HSCT between 1998 and 2000 (study II, n=41). We found a lower prevalence of children with chronic renal failure (CRF) post-HSCT in our more recent cohort (study II: 10%) as compared to the older cohort (study I: 24%) 5.0 (0.7 s.d.) and 7.6 (2.4 s.d.) year's post-HSCT, respectively. Furthermore, it seems that renal function may stabilize after 1-year post-HSCT. None of the patients required dialysis or antihypertensive medication at long-term follow-up. The sole predictor of CRF in our study was high serum creatinine pre-HSCT (P=0.007), while acute renal failure within 3 months after HSCT (P=0.08) only showed a trend towards predicting CRF. We could not confirm a relation of conditioning with irradiation with CRF post-HSCT, as was shown in several other pediatric and adult studies. Proximal and distal tubular dysfunction only occurred in a minority of long-time survivors of HSCT (3-12 and 9-13%, respectively) and had no clinical consequences.

Indexed as

ChildCohort StudiesCreatinineFemaleFollow-Up StudiesGlomerular Filtration RateHematopoietic Stem Cell TransplantationHumansKidneyKidney Failure, ChronicKidney TubulesMalePrevalenceProspective StudiesRegression AnalysisRetrospective StudiesCreatinine

Identifiers

PMID16044134
OpenAlexW2070986357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.