ArticleNucleic acids research2005
Cloning and characterization of the Schizosaccharomyces pombe homologs of the human protein Translin and the Translin-associated protein TRAX.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Translin facilitates RNA polymerase II dissociation and suppresses genome instability during RNase H2- and Dicer-deficiency.PLoS genetics · 2022Article
- Translin: A multifunctional protein involved in nucleic acid metabolism.Journal of biosciences · 2019Review
- GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons.Molecular psychiatry · 2018Article
- The dynamic landscape of fission yeast meiosis alternative-splice isoforms.Genome research · 2017Article
- Structural basis for single-stranded RNA recognition and cleavage by C3PO.Nucleic acids research · 2016Article
- Translin and Trax differentially regulate telomere-associated transcript homeostasis.Oncotarget · 2016Article
- Characterization of a plant (rice) translin and its comparative analysis with human translin.Planta · 2014Article
- Conformational transitions in human translin enable nucleic acid binding.Nucleic acids research · 2013Article
- The translin-TRAX complex (C3PO) is a ribonuclease in tRNA processing.Nature structural & molecular biology · 2012Article
- Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.Nature structural & molecular biology · 2011Article
- Mapping of interaction sites of the Schizosaccharomyces pombe protein Translin with nucleic acids and proteins: a combined molecular genetics and bioinformatics study.Nucleic acids research · 2010Article
- The Translin/Trax RNA binding complex: clues to function in the nervous system.Biochimica et biophysica acta · 2008Review
- Functional characterization of Drosophila Translin and Trax.Genetics · 2006Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Translin is a human octameric protein that specifically binds the single-stranded microsatellite repeats d(GT)n and the corresponding transcripts (GU)n. It also binds, with lesser affinities, other single-stranded G-rich DNA and RNA sequences. TRAX is a human protein that bears a homology to Translin and interacts with it. Translin and TRAX have been proposed to be involved in DNA recombination, chromosomal translocation and mRNA transport and translation. Both proteins are highly conserved in eukaryotes, including the fission yeast Schizosaccharomyces pombe, which is amenable to genetic analysis. Here, we report the first study of the S.pombe Translin and TRAX homologs. We have deleted the genes encoding Translin and TRAX in S.pombe and found that the proliferation of the mutant cells was slightly stimulated, suggesting that these genes are not essential for the fission yeast. We have also shown that the S.pombe Translin and TRAX interact. Biochemical analysis of the S.pombe Translin, which was cloned and expressed in Escherichia coli, revealed that it is octameric and that it selectively binds d(GT)n and d(GTT)n microsatellite repeats. However, unlike the human protein, it has much higher affinities for the homologous RNA sequences (GU)n and (GUU)n. These data suggest that the S.pombe Translin is primarily involved in functions related to RNA metabolism.
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